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Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
dc.contributor.author | Angarita Dávila, Lisse Chiquinquira | |
dc.contributor.author | Bermúdez Pirela, Valmore José | |
dc.contributor.author | Aparicio, Daniel | |
dc.contributor.author | Céspedes, Virginia | |
dc.contributor.author | Escobar, M. Cristina | |
dc.contributor.author | Durán-Agüero, Samuel | |
dc.contributor.author | Cisternas, Silvia | |
dc.contributor.author | Costa, Jorge de Assis | |
dc.contributor.author | Rojas-Gómez, Diana | |
dc.contributor.author | Reyna Villasmil, Nadia Yra | |
dc.contributor.author | López-Miranda, José | |
dc.date.accessioned | 2019-06-28T12:20:38Z | |
dc.date.available | 2019-06-28T12:20:38Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | http://hdl.handle.net/10396/18778 | |
dc.description.abstract | Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial e ects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p < 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Nutrients 11, 1477 (2019) | es_ES |
dc.subject | Glycaemic index | es_ES |
dc.subject | Incretins | es_ES |
dc.subject | Subjective appetite | es_ES |
dc.subject | Isomaltulose | es_ES |
dc.subject | Sucromalt | es_ES |
dc.subject | Nutritional supplement | es_ES |
dc.title | Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3390/nu11071477 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |