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dc.contributor.authorEsteras, Raquel
dc.contributor.authorFox, Jonathan G.
dc.contributor.authorGeddes, Colin C.
dc.contributor.authorMackinnon, Bruce
dc.contributor.authorOrtiz, Alberto
dc.contributor.authorMoreno, Juan Antonio
dc.date.accessioned2020-07-07T19:32:18Z
dc.date.available2020-07-07T19:32:18Z
dc.date.issued2020
dc.identifier.urihttp://hdl.handle.net/10396/20297
dc.description.abstractAcute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury. Although haematuria is a risk factor for the development of renal disease, no previous study has analyzed the significance of haematuria in ATIN. Retrospective, observational analysis of 110 patients with biopsy-proven ATIN was conducted. Results: Haematuria was present in 66 (60%) ATIN patients. A higher percentage of ATIN patients with haematuria had proteinuria than patients without haematuria (89.4% vs. 59.1%, p = 0.001) with significantly higher levels of proteinuria (median (interquartile range) protein:creatinine ratio 902.70 (513–1492) vs. 341.00 (177–734) mg/g, p <0.001). Moreover, those patients with more haematuria intensity had a higher urinary protein:creatinine ratio (1352.65 (665–2292) vs. 849.60 (562–1155) mg/g, p = 0.02). Those patients with higher proteinuria were more likely to need renal replacement therapy (22.7 vs. 0%, p = 0.03) and to suffer relapse (4 vs. 0%, p = 0.03). At the end of follow up, haematuric ATIN patients had higher serum creatinine levels (3.19 ± 2.91 vs. 1.91 ± 1.17 mg/dL, p = 0.007), and a trend towards a higher need for acute dialysis (7 vs. 1%, p = 0.09) and renal replacement therapy (12.1 vs. 2.3%, p = 0.12). Haematuria is common in ATIN and it is associated with worse renal function outcomes.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceJournal of Clinical Medicine 9(7), 2135 (2020)es_ES
dc.subjectAcute kidney injuryes_ES
dc.subjectAcute tubulointerstitial nephritises_ES
dc.subjectHaematuriaes_ES
dc.subjectKidney biopsyes_ES
dc.subjectOutcomeses_ES
dc.subjectProteinuriaes_ES
dc.subjectChronic kidney diseasees_ES
dc.titleHematuria Is Associated with More Severe Acute Tubulointerstitial Nephritises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/jcm9072135es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI17/00130es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI19/00815es_ES
dc.relation.projectIDGobierno de España. RYC-2017-22369es_ES
dc.relation.projectIDGobierno de España. DTS18/00032es_ES
dc.relation.projectIDInstituto de Salud Carlos III. RD016/0009es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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