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A discontinuous DNA glycosylase domain in a family of enzymes that excise 5-methylcytosine
(Oxford University Press, 2011)
DNA cytosine methylation (5-meC) is a widespread
epigenetic mark associated to gene silencing. In
plants, DEMETER-LIKE (DML) proteins typified by
Arabidopsis REPRESSOR OF SILENCING 1 (ROS1)
initiate active DNA demethylation ...
Homologous Recombination Is Stimulated by a Decrease in dUTPase in Arabidopsis
(Public Library Of Science (PLOS), 2011)
Deoxyuridine triphosphatase (dUTPase) enzyme is an essential enzyme that protects DNA against uracil incorporation. No
organism can tolerate the absence of this activity. In this article, we show that dUTPase function is ...
An AP Endonuclease Functions in Active DNA Demethylation and Gene Imprinting in Arabidopsis
(Public Library of Science, 2015)
Active DNA demethylation in plants occurs through base excision repair, beginning with removal of methylated cytosine by
the ROS1/DME subfamily of 5-methylcytosine DNA glycosylases. Active DNA demethylation in animals ...
The DNA Repair Protein XRCC1 Functions in the Plant DNA Demethylation Pathway by Stimulating Cytosine Methylation (5-meC) Excision, Gap Tailoring, and DNA Ligation
(JBC, 2013)
Background: Active DNA demethylation in plants is initiated by 5-meC DNA glycosylases of the ROS1/DME family and
continued through a base excision repair pathway.
Results: XRCC1 stimulates ROS1-initiated demethylation ...