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dc.contributor.authorEspejo-Cruz, María Lola
dc.contributor.authorGonzález Rubio, Sandra
dc.contributor.authorZamora-Olaya, Javier
dc.contributor.authorAmado-Torres, Víctor
dc.contributor.authorAlejandre, Rafael
dc.contributor.authorSánchez-Frías, Marina
dc.contributor.authorCiria, Rubén
dc.contributor.authorMata, Manuel de la
dc.contributor.authorRodríguez-Perálvarez, Manuel
dc.contributor.authorFerrín, Gustavo
dc.date.accessioned2021-12-03T11:57:17Z
dc.date.available2021-12-03T11:57:17Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10396/22198
dc.description.abstractHepatocellular carcinoma (HCC) is the fifth most common neoplasm and a major cause of cancer-related death worldwide. There is no ideal biomarker allowing early diagnosis of HCC and tumor surveillance in patients receiving therapy. Liquid biopsy, and particularly circulating tumor cells (CTCs), have emerged as a useful tool for diagnosis and monitoring therapeutic responses in different tumors. In the present manuscript, we evaluate the current evidence supporting the quantitative and qualitative assessment of CTCs as potential biomarkers of HCC, as well as technical aspects related to isolation, identification, and classification of CTCs. Although the dynamic assessment of CTCs in patients with HCC may aid the decision-making process, there are still many uncertainties and technical caveats to be solved before this methodology has a true impact on clinical practice guidelines. More studies are needed to identify the optimal combination of surface markers, to increase the efficiency of ex-vivo expansion of CTCs, or even to target CTCs as a potential therapeutic strategy to prevent HCC recurrence after surgery or to hamper tumor progression and extrahepatic spreading.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceInternational Journal of Molecular Sciences 22(23), 13073 (2021)es_ES
dc.subjectHepatocellular carcinomaes_ES
dc.subjectLiquid biopsyes_ES
dc.subjectCirculating tumor cellses_ES
dc.subjectDynamic changeses_ES
dc.subjectTherapeutic targetes_ES
dc.titleCirculating Tumor Cells in Hepatocellular Carcinoma: A Comprehensive Review and Critical Appraisales_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms222313073es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI18/01736es_ES
dc.relation.projectIDJunta de Andalucía. RH-0075-2020es_ES
dc.relation.projectIDInstituto de Salud Carlos III. FI19/00357es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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