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    • A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study 

      Villasanta-González, Alejandro; Alcalá Díaz, Juan Francisco; Vals-Delgado, Cristina; Arenas, Antonio Pablo; Cardelo, Magdalena P.; Romero-Cabrera, Juan Luis; Rodríguez-Cantalejo, Fernando; Delgado-Lista, Javier; Malagón, María M.; Pérez-Martínez, Pablo; Schulze, Matthias B.; Camargo García, A.; López-Miranda, José (Springer, 2021)
      Purpose: The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. For this reason, it is essential to identify biomarkers for the early detection of T2DM risk and/or for a better prognosis of T2DM. We ...

    • Association between Diet Quality and Risk of Type 2 Diabetes Mellitus in Patients with Coronary Heart Disease: Findings from the CORDIOPREV Study 

      Rivas García, Lorenzo; Quintana-Navarro, Gracia M.; Alcalá Díaz, Juan Francisco; Torres‑Peña, J.D.; Arenas de Larriva, Antonio P.; Rangel-Zuñiga, Oriol Alberto; López-Moreno, Alejandro; Malagón, María M.; Katsiki, Niki; Pérez Martínez, Pablo; López Miranda, José; Delgado-Lista, Javier (MDPI, 2024)
      The incidence of type 2 diabetes mellitus (T2DM) is growing in Western countries. Nutritional interventions that promote high-quality dietary patterns could help reverse this trend. We aimed to evaluate whether changes in ...

    • Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial 

      Roncero-Ramos, Irene; Gutiérrez Mariscal, Francisco Miguel; Gómez Delgado, Francisco; Villasanta-González, Alejandro; Torres‑Peña, J.D.; Cruz‐Ares, Silvia de la; Rangel Zúñiga, Oriol Alberto; Luque, Raúl M.; Ordovas, José M.; Delgado-Lista, Javier; Pérez-Martínez, Pablo; Camargo García, A.; Alcalá Díaz, Juan Francisco; López-Miranda, José (Elsevier, 2021)
      In order to assess whether previous hepatic IR (Hepatic-IR fasting) and beta-cell functionality could modulate type 2 diabetes remission and the need for starting glucose- lowering treatment, newly-diagnosed type 2 diabetes ...

    • Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study 

      Alcalá Díaz, Juan Francisco; Limia-Pérez, Laura; Gómez-Huelgas, Ricardo; Martín-Escalante, María D.; Cortés Rodríguez, Begoña; Zambrana-García, José L.; Entrenas-Castillo, Marta; Pérez-Caballero, Ana I.; López-Carmona, María D.; García-Alegría, Javier; Lozano Rodríguez-Mancheño, Aquiles; Arenas-de Larriva, María del Sol; Pérez-Belmonte, Luis M.; Jungreis, Irwin; Bouillon, Roger; Quesada Gómez, José Manuel; López-Miranda, José (MDPI, 2021)
      Context. Calcifediol has been proposed as a potential treatment for COVID-19 patients. Objective: To compare the administration or not of oral calcifediol on mortality risk of patients hospitalized because of COVID-19. ...

    • Diabetes Remission Is Modulated by Branched Chain Amino Acids According to the Diet Consumed: From the CORDIOPREV Study 

      Cardelo, Magdalena P.; Alcalá Díaz, Juan Francisco; Gutiérrez Mariscal, Francisco Miguel; López Moreno, Javier; Villasanta-González, Alejandro; Arenas de Larriva, Antonio P.; Cruz Ares, Silvia de la; Delgado-Lista, Javier; Rodríguez-Cantalejo, Fernando; Luque, Raúl M.; Ordovás, José María; Pérez Martínez, Pablo; Camargo García, A.; López Miranda, José (Wiley, 2021)
      Scope: Branched Chain Amino Acids (BCAA) plasma levels may be differentially associated with type 2 diabetes mellitus (T2DM) remission through the consumption of the Mediterranean diet (Med) and a low-fat (LF) diet. Methods: ...

    • Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study 

      Hidalgo-Moyano, Cristina; Rangel-Zuñiga, Oriol Alberto; Gómez Delgado, Francisco; Alcalá Díaz, Juan Francisco; Rodríguez-Cantalejo, Fernando; Yubero-Serrano, Elena M.; Torres‑Peña, J.D.; Arenas de Larriva, Antonio P.; Camargo García, A.; Pérez-Martínez, Pablo; López-Miranda, José; Delgado-Lista, Javier (MDPI, 2022)
      We investigated whether long-term consumption of two healthy diets (low-fat (LF) or Mediterranean (Med)) interacts with SIRT1 genotypes to modulate aging-related processes such as leucocyte telomere length (LTL), oxidative ...

    • Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study 

      Martín-Piedra, Laura; Alcalá Díaz, Juan Francisco; Gutiérrez Mariscal, Francisco Miguel; Arenas de Larriva, Antonio P.; Romero-Cabrera, Juan Luis; Torres‑Peña, J.D.; Caballero-Villarraso, Javier; Luque, Raúl M.; Pérez-Martínez, Pablo; López-Miranda, José; Delgado-Lista, Javier (MDPI, 2021)
      Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing ...

    • Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study 

      León Acuña, Ana; Delgado Lista, José; Torres‑Peña, J.D.; López Moreno, Javier; García-Ríos, Antonio; Marín, Carmen; Gómez Delgado, Francisco; Caballero, J.; Van‑Ommen, B.; Malagón, María M.; Pérez-Martínez, Pablo; Alcalá Díaz, Juan Francisco; Camargo García, A.; López-Miranda, José (BioMed Central, 2016)
      Background/aims: Previous evidences have shown the presence of a prolonged and exaggerated postprandial response in type 2 diabetes mellitus (T2DM) and its relation with an increase of cardiovascular risk. However, ...

    • Hypertriglyceridemia Influences the Degree of Postprandial Lipemic Response in Patients with Metabolic Syndrome and Coronary Artery Disease: From the Cordioprev Study 

      Alcalá Díaz, Juan Francisco; Delgado-Lista, Javier; Pérez-Martínez, Pablo; Quintana-Navarro, Gracia M.; Gómez-Luna, Purificación; Camargo García, A.; Almadén Peña, Yolanda; Caballero, Javier; Marín, Carmen; García-Ríos, Antonio; Tinahones, Francisco J.; Ordovas, José M.; Pérez-Jímenez, Francisco; López-Miranda, José (PLOS, 2014)
      Objective To determine whether metabolic syndrome traits influence the postprandial lipemia response of coronary patients, and whether this influence depends on the number of MetS criteria. Materials and Methods 1002 ...

    • Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study) 

      Talavera-García, Eva; Delgado-Lista, Javier; García-Ríos, Antonio; Delgado-Casado, Nieves; Gómez-Luna, Purificación; Gómez-Garduño, Ángela; Gómez Delgado, Francisco; Alcalá Díaz, Juan Francisco; Yubero-Serrano, Elena M.; Marín, Carmen; Pérez-Caballero, Ana I.; Fuentes-Jiménez, Francisco J.; Rodríguez-Cantalejo, Fernando; Tinahones, Francisco J.; Ordovás, José María; Pérez-Jiménez, Francisco; Pérez-Martínez, Pablo; López-Miranda, José; Camargo García, A. (Public Library of Science, 2016)
      Background Recent data suggest that the presence of associated metabolic abnormalities may be important modifiers of the association of obesity with a poorer prognosis in coronary heart disease. We determined the influence ...

    • Long-term effect of a dietary intervention with two-healthy dietary approaches on food intake and nutrient density in coronary patients: results from the CORDIOPREV trial 

      Cano‑Ibáñez, Naomi; Quintana-Navarro, Gracia M.; Alcalá Díaz, Juan Francisco; Rangel Zúñiga, Oriol Alberto; Camargo García, A.; Yubero-Serrano, Elena M.; Pérez‑Corral, Isabel; Arenas de Larriva, Antonio P.; García-Ríos, Antonio; Pérez-Martínez, Pablo; Delgado-Lista, Javier; López-Miranda, José (Springer, 2022)
      Background: Cardiovascular disease (CVD) is the leading cause of disease burden in the world by non-communicable diseases. Nutritional interventions promoting high-quality dietary patterns with low caloric intake value and ...

    • Mediterranean Diet and Endothelial Function: A Review of Its Effects at Different Vascular Bed Levels 

      Torres‑Peña, J.D.; Rangel Zúñiga, Oriol Alberto; Alcalá Díaz, Juan Francisco; López-Miranda, José; Delgado-Lista, Javier (MDPI, 2020)
      The Mediterranean diet has recently been the focus of considerable attention as a palatable model of a healthy diet. Its influence on many cardiovascular risk factors, combined with its proven effect in reducing the risk ...

    • Owning a Pet Is Associated with Changes in the Composition of Gut Microbiota and Could Influence the Risk of Metabolic Disorders in Humans 

      Arenas-Montes, Javier; Pérez-Martínez, Pablo; Vals-Delgado, Cristina; Romero-Cabrera, Juan Luis; Cardelo, Magdalena P.; León Acuña, Ana; Quintana-Navarro, Gracia M.; Alcalá Díaz, Juan Francisco; López-Miranda, José; Camargo García, A.; Pérez-Jiménez, Francisco (MDPI, 2021)
      Pet ownership positively influences clinical outcomes in cardiovascular prevention. Additionally, cardiovascular disease (CVD) has been previously linked to microbiota dysbiosis. We evaluated the influence of owning a pet ...

    • Quality and Quantity of Protein Intake Influence Incidence of Type 2 Diabetes Mellitus in Coronary Heart Disease Patients: From the CORDIOPREV Study 

      Cruz‐Ares, Silvia de la; Gutiérrez Mariscal, Francisco Miguel; Alcalá Díaz, Juan Francisco; Quintana-Navarro, Gracia M.; Podadera-Herreros, Alicia; Cardelo, Magdalena P.; Torres‑Peña, J.D.; Arenas de Larriva, Antonio P.; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; López-Miranda, José (MDPI, 2021)
      Evidence suggests that enriching a diet with plant-based proteins could reduce the risk of developing type 2 diabetes mellitus. In the present work, we evaluated the association between the change in plant protein intake ...

    • Telomere maintenance is associated with type 2 diabetes remission in response to a long-term dietary intervention without non-weight loss in patients with coronary heart disease: from the CORDIOPREV randomized controlled trial 

      Ojeda-Rodríguez, Ana; Alcalá Díaz, Juan Francisco; Rangel Zúñiga, Oriol Alberto; Arenas de Larriva, Antonio P.; Gutiérrez Mariscal, Francisco Miguel; Torres‑Peña, J.D.; Mora-Ortiz, Marina; Romero-Cabrera, Juan Luis; Luque, Raúl M.; Ordovas, José M.; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; López-Miranda, José (MDPI, 2024)
      In order to evaluate whether telomere maintenance is associated with type 2 diabetes remission, newly diagnosed type 2 diabetes patients without glucose-lowering treatment (183 out of 1002) from the CORDIOPREV study ...