Listar DMed-Artículos, capítulos... por autor "8094cc49-456c-4c3d-948d-cb8239770e5b"
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A polymorphism exon 1 variant at the locus of the scavenger receptor class B type I (SCARB1) gene is associated with differences in insulin sensitivity in healthy people during the consumption of an olive oil-rich diet
Pérez-Martínez, Pablo; Pérez-Jiménez, Francisco; Bellido, Cecilia; Ordovas, José M.; Moreno, Juan Antonio; Marín, Carmen; Gómez, Purificación; Delgado-Lista, Javier; Fuentes, Francisco; López Miranda, José (Oxford Academic, 2005)Scavenger receptor class B type I (SCARB1) was described as the first high-density lipoprotein receptor. Increasing evidence indicates that SCARB1 plays additional roles particularly in type 2 diabetes mellitus. Our aim ... -
A single nucleotide polymorphism of the apolipoprotein A-V gene -1131T>C modulates postprandial lipoprotein metabolism
Moreno, Rafael; Pérez-Jiménez, Francisco; Marín, Carmen; Moreno, Juan Antonio; Gómez, Purificación; Bellido, Cecilia; Pérez Martínez, Pablo; Jiménez Gómez, Yolanda; José Fuentes, Francisco; López Miranda, José (Elsevier, 2006)The Apolipoprotein A–V (apoA–V) gene promoter polymorphism −1131T > C modulates triacylglycerol (TG) concentrations. We evaluate whether this polymorphism could be involved in the interindividual variability observed during ... -
Apolipoprotein E gene promoter -219G->T polymorphism increases LDL-cholesterol concentrations and susceptibility to oxidation in response to a diet rich in saturated fat.
Moreno, Juan Antonio; Pérez-Jiménez, Francisco; Marín, Carmen; Gómez, Purificación; Pérez-Martínez, Pablo; Moreno, Rafael; Bellido, Cecilia; Fuentes, Francisco; López Miranda, José (Elsevier, 2004)Background The apolipoprotein E (APOE) gene promoter polymorphism (−219G→T) has been associated with increased risk of myocardial infarction, premature coronary artery disease, and decreased plasma apolipoprotein E ... -
Cerivastatin Improves Insulin Sensitivity and Insulin Secretion in Early-State Obese Type 2 Diabetes
Paniagua, Juan Antonio; López Miranda, José; Escribano, A.; Berral de la Rosa, Francisco José; Marín, Carmen; Bravo, D.; Paz-Rojas, Elier; Gómez, Purificación; Barcos, Montserrat; Moreno, Juan Antonio; Pérez-Jiménez, Francisco (American Diabetes Association, 2002) -
Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations
Pérez-Caballero, Ana I.; García-Ríos, Antonio; Gómez-Luna, María J.; Gómez-Luna, Purificación; Dembinska-Kiec, Aldona; Rodríguez-Cantalejo, Fernando; Camargo García, A.; Marín, Carmen; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; Tinahones, Francisco J.; Pérez-Jiménez, Francisco; Roche, Helen M.; López-Miranda, José (Public Library Of Science (PLOS), 2012)Background: TCF7L2 rs7903146 is an important genetic factor predicting type 2 diabetes (T2DM) which has also been linked to higher cardiovascular risk. To date, there is little information about the additional impact of ... -
Endothelial Aging Associated with Oxidative Stress Can Be Modulated by a Healthy Mediterranean Diet
Marín, Carmen; Yubero-Serrano, Elena M.; Pérez-Jiménez, Francisco; López-Miranda, José (MDPI, 2013)Aging is a condition which favors the development of atherosclerosis, which has been associated with a breakdown in repair processes that occurs in response to cell damage. The dysregulation of the biological systems ... -
Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study
León Acuña, Ana; Delgado Lista, José; Torres‑Peña, J.D.; López Moreno, Javier; García-Ríos, Antonio; Marín, Carmen; Gómez Delgado, Francisco; Caballero, J.; Van‑Ommen, B.; Malagón, María M.; Pérez-Martínez, Pablo; Alcalá Díaz, Juan Francisco; Camargo García, A.; López-Miranda, José (BioMed Central, 2016)Background/aims: Previous evidences have shown the presence of a prolonged and exaggerated postprandial response in type 2 diabetes mellitus (T2DM) and its relation with an increase of cardiovascular risk. However, ... -
Hypertriglyceridemia Influences the Degree of Postprandial Lipemic Response in Patients with Metabolic Syndrome and Coronary Artery Disease: From the Cordioprev Study
Alcalá Díaz, Juan Francisco; Delgado-Lista, Javier; Pérez-Martínez, Pablo; Quintana-Navarro, Gracia M.; Gómez-Luna, Purificación; Camargo García, A.; Almadén Peña, Yolanda; Caballero, Javier; Marín, Carmen; García-Ríos, Antonio; Tinahones, Francisco J.; Ordovas, José M.; Pérez-Jímenez, Francisco; López-Miranda, José (PLOS, 2014)Objective To determine whether metabolic syndrome traits influence the postprandial lipemia response of coronary patients, and whether this influence depends on the number of MetS criteria. Materials and Methods 1002 ... -
Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study)
Talavera-García, Eva; Delgado-Lista, Javier; García-Ríos, Antonio; Delgado-Casado, Nieves; Gómez-Luna, Purificación; Gómez-Garduño, Ángela; Gómez Delgado, Francisco; Alcalá Díaz, Juan Francisco; Yubero-Serrano, Elena M.; Marín, Carmen; Pérez-Caballero, Ana I.; Fuentes-Jiménez, Francisco J.; Rodríguez-Cantalejo, Fernando; Tinahones, Francisco J.; Ordovás, José María; Pérez-Jiménez, Francisco; Pérez-Martínez, Pablo; López-Miranda, José; Camargo García, A. (Public Library of Science, 2016)Background Recent data suggest that the presence of associated metabolic abnormalities may be important modifiers of the association of obesity with a poorer prognosis in coronary heart disease. We determined the influence ... -
Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids
Rangel Zúñiga, Oriol Alberto; Camargo García, A.; Marín, Carmen; Peña Orihuela, Judhit; Pérez-Martínez, Pablo; Delgado-Lista, Javier; González Guardia, Lorena; Yubero-Serrano, Elena M.; Tinahones, Francisco J.; Malagón, María M.; Pérez-Jiménez, Francisco; Roche, Helen M.; López-Miranda, José (BioMed Central, 2015)Background: Metabolic syndrome is a multi-component disorder associated to a high risk of cardiovascular disease. Its etiology is the result of a complex interaction between genetic and environmental factors, including ... -
The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population
Pérez Martínez, Pablo; Pérez Jiménez, Francisco; Ordovás, José María; Bellido, Cecilia; Moreno, Juan; Gómez, Purificación; Marín, Carmen; Fernández de la Puebla, Rafael Ángel; Paniagua, Juan Antonio; López Miranda, José (Elsevier, 2007)Our goal was to determine whether the presence of the −516C/T polymorphism in the APOB gene promoter modifies the lipid response to changes in the amount and quality of dietary fat. We studied 97 young healthy volunteers ... -
The Apolipoprotein E Gene Promoter (−219G/T) Polymorphism Determines Insulin Sensitivity in Response to Dietary Fat in Healthy Young Adults
Moreno, Juan Antonio; Pérez-Jiménez, Francisco; Marín, Carmen; Pérez-Martínez, Pablo; Moreno, Rafael; Gómez, Purificación; Jiménez Gómez, Yolanda; Paniagua, Juan Antonio; Lairon, Denis; López Miranda, José (Elsevier, 2005)Insulin sensitivity (IS) is determined by genetic and environmental factors, including diet. The apoE gene promoter −219G/T polymorphism is associated with coronary heart disease and increased postprandial triacylglycerol-rich ... -
The Effect of Dietary Fat on LDL Size Is Influenced by Apolipoprotein E Genotype in Healthy Subjects
Moreno, Juan Antonio; Pérez-Jiménez, Francisco; Marín, Carmen; Gómez, Purificación; Pérez-Martínez, Pablo; Moreno, Rafael; Bellido, Cecilia; Fuentes, Francisco; López Miranda, José (American Society for Nutrition, 2004)LDL particle size is dependent on both genetic factors and environmental factors such as dietary fat composition. The apolipoprotein E (apoE) genotype is a major genetic determinant of LDL size. Thus, the aim of this work ... -
The influence of the apolipoprotein E gene promoter (-219G/T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males
Moreno, Juan Antonio; López Miranda, José; Marín, Carmen; Paniagua, Juan Antonio; Ordovas, José M.; Pérez-Jiménez, Francisco (ASBMB, 2003)The apolipoprotein E (apoE) gene promoter (−219G/T) polymorphism has been associated with increased risk of myocardial infarction, premature coronary heart disease, and decreased plasma apoE concentrations. We examined ... -
Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy caucasian population
Moreno-Luna, Rafael; Pérez Jiménez, Francisco; Marín, Carmen; Pérez Martínez, Pablo; Gómez, Purificación; Jiménez Gómez, Yolanda; Delgado-Lista, Javier; Moreno, Juan; Tanaka, Toshiko; Ordovás, José María; López Miranda, José (Endocrine Society, 2007)Background: Apolipoprotein A5 (APOA5) plays an important role in plasma triacylglycerol (TG) homeostasis. Five polymorphisms (1131T>C, c.-3A>G, c.56C>G, IVS3+476G>A, and c.1259T>C) in the APOA5 gene define three common ...