• Caloric Intake in Renal Patients: Repercussions on Mineral Metabolism 

      Vidal, Ángela; Ríos, Rafael; Pineda, Carmen; López, Ignacio; Raya, Ana I.; Aguilera Tejero, Escolástico; Rodríguez, Mariano (MDPI, 2020)
      The aim of this paper is to review current knowledge about how calorie intake influences mineral metabolism focussing on four aspects of major interest for the renal patient: (a) phosphate (P) handling, (b) fibroblast ...
    • Energy-Dense Diets and Mineral Metabolism in the Context of Chronic Kidney Disease–Metabolic Bone Disease (CKD-MBD) 

      Rodríguez, Mariano; Aguilera Tejero, Escolástico (MDPI, 2018)
      The aim of this paper is to review current knowledge about the interactions of energy-dense diets and mineral metabolism in the context of chronic kidney disease–metabolic bone disease (CKD-MBD). Energy dense-diets promote ...
    • Energy-dense diets increase FGF23, lead to phosphorus retention and promote vascular calcifications in rats 

      Raya, Ana I.; Ríos, Rafael; Pineda Martos, Carmen María; Rodríguez-Ortiz, Maria E.; Díez, Elisa; Almadén Peña, Yolanda; Muñoz-Castañeda, Juan R.; Rodríguez, Mariano; Aguilera Tejero, Escolástico; López, Ignacio (Nature.com, 2016)
      Rats with normal renal function (Experiment 1, n = 12) and uninephrectomized (1/2Nx) rats (Experiment 2, n = 12) were fed diets with normal P (NP) and either normal (NF) or high fat (HF). Rats with intact renal function ...
    • Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake 

      Pineda Martos, Carmen María; Ríos, Rafael; Raya, Ana I.; Rodríguez, Mariano; Aguilera Tejero, Escolástico; López, Ignacio (MDPI, 2018)
      The effect of dietary phosphorus (P) on fibroblast growth factor 21 (FGF21)/ -klotho axis was investigated in rats that were fed diets with: Normal (NP) or high P (HP) and either normal (NC), high (HC) or low calories ...
    • Oral Acid Load Down-Regulates Fibroblast Growth Factor 23 

      Vidal, Ángela; Pineda, Carmen; Raya, Ana I.; Ríos, Rafael; Espartero, Azahara; Muñoz-Castañeda, Juan R.; Rodríguez, Mariano; Aguilera Tejero, Escolástico; López, Ignacio (MDPI, 2022)
      Increased dietary acid load has a negative impact on health, particularly when renal function is compromised. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that is elevated during renal failure. The ...
    • Phosphorus restriction does not prevent the increase in fibroblast growth factor 23 elicited by high fat diet 

      Ríos, Rafael; Pineda Martos, Carmen María; López, Ignacio; Muñoz-Castañeda, Juan R.; Rodríguez, Mariano; Aguilera Tejero, Escolástico; Raya, Ana I. (Public Library of Science, 2018)
      This study was designed to evaluate the influence of phosphorus (P) restriction on the dele- terious effects of high fat diets on mineral metabolism. Twenty-four rats were allotted to 3 groups (n ...
    • Vitamin E protects against extraskeletal calcification in uremic rats fed high fat diets 

      Ríos, Rafael; Raya, Ana I.; Pineda Martos, Carmen María; Rodríguez, Mariano; López, Ignacio; Aguilera Tejero, Escolástico (Biomed Central, 2017)
      Background: High fat diets are implicated in the pathogenesis of metabolic syndrome, obesity and renal disease. Previous studies have revealed that high fat diets promote vascular calcification in uremic rats. Moreover, ...