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dc.contributor.authorFernandois, Daniela
dc.contributor.authorVázquez, María J.
dc.contributor.authorBarroso, Alexia
dc.contributor.authorParedes, Alfonso H.
dc.contributor.authorTena-Sempere, Manuel
dc.contributor.authorCruz, Gonzalo
dc.date.accessioned2023-12-14T11:48:05Z
dc.date.available2023-12-14T11:48:05Z
dc.date.issued2023
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10396/26352
dc.description.abstractAutonomic innervation is important to regulate homeostasis in every organ of the body. The sympathetic nervous system controls several organs associated with metabolism and reproduction, including adipose tissue, the liver, and the ovaries. The sympathetic nervous system is controlled within the central nervous system by neurons located in the hypothalamus, which in turn are regulated by hormones like leptin. Leptin action in the hypothalamus leads to increased sympathetic activity in the adipose tissue. In this short report, we propose that leptin action in the brain also controls the sympathetic innervation of other organs like the liver and the ovary. We performed two experiments: We performed an intracerebroventricular (ICV) injection of leptin and measured norepinephrine levels in several organs, and we used a validated model of overnutrition and obesity to evaluate whether an increase in leptin levels coexists with high levels of norepinephrine in the liver and ovaries. Norepinephrine was measured by ELISA in adipose tissue and by HPLC-EC in other tissues. Leptin was measured by ELISA. We found that the ICV injection of leptin increases norepinephrine levels in several organs, including the liver and ovaries. Also, we found that diet-induced obesity leads to an increase in leptin levels while inducing an increase in norepinephrine levels in the liver and ovaries. Finally, since hyperactivity of the sympathetic nervous system is observed both in non-alcoholic fatty liver disease and polycystic ovary syndrome, we think that an increase in norepinephrine levels induced by hyperleptinemia could be involved in the pathogenesis of both diseases.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceInt. J. Mol. Sci., 24(23), 16909 (2023)es_ES
dc.subjectLeptines_ES
dc.subjectNorepinephrinees_ES
dc.subjectSympathetic nervous systemes_ES
dc.subjectOvaryes_ES
dc.subjectLiveres_ES
dc.subjectFates_ES
dc.titleMulti-organ increase in Norepinephrine levels after central leptin administration and diet-induced obesityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms242316909es_ES
dc.relation.projectIDGobierno de España. FONDECYT-ANID 1201816es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.relation.referencesDatos de investigación en: https://www.mdpi.com/article/10.3390/ijms242316909/s1


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