Electrochemiluminescent nanostructured DNA biosensor for SARS-CoV-2 detection
Autor
Gutiérrez-Gálvez, Laura
Del Caño-Ochoa, Rafael
Menéndez-Luque, Iris
García-Nieto, Daniel
Rodríguez-Peña, Micaela
Luna, Mónica
Pineda, Teresa
Pariente, Félix
García-Mendiola, Tania
Lorenzo, Encarnación
Editor
ElsevierFecha
2022Materia
AuNMsDNA biosensor
SARS-CoV-2
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This work focuses on the development of an electrochemiluminescent nanostructured DNA biosensor for SARSCoV-
2 detection. Gold nanomaterials (AuNMs), specifically, a mixture of gold nanotriangles (AuNTs) and gold
nanoparticles (AuNPs), are used to modified disposable electrodes that serve as an improved nanostructured
electrochemiluminescent platform for DNA detection. Carbon nanodots (CDs), prepared by green chemistry, are
used as coreactants agents in the [Ru(bpy)3]2+ anodic electrochemiluminescence (ECL) and the hybridization is
detected by changes in the ECL signal of [Ru(bpy)3]2+/CDs in combination with AuNMs nanostructures. The
biosensor is shown to detect a DNA sequence corresponding to SARS-CoV-2 with a detection limit of 514 aM.