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The influence of the apolipoprotein E gene promoter (-219G/T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males
dc.contributor.author | Moreno, Juan Antonio | |
dc.contributor.author | López Miranda, José | |
dc.contributor.author | Marín, Carmen | |
dc.contributor.author | Paniagua, Juan Antonio | |
dc.contributor.author | Ordovas, José M. | |
dc.contributor.author | Pérez-Jiménez, Francisco | |
dc.date.accessioned | 2024-02-08T23:01:25Z | |
dc.date.available | 2024-02-08T23:01:25Z | |
dc.date.issued | 2003 | |
dc.identifier.uri | http://hdl.handle.net/10396/27343 | |
dc.description.abstract | The apolipoprotein E (apoE) gene promoter (−219G/T) polymorphism has been associated with increased risk of myocardial infarction, premature coronary heart disease, and decreased plasma apoE concentrations. We examined whether the −219G/T polymorphism could modify the postprandial response of triacylglycerol-rich lipoproteins (TRLs). Fifty-one healthy apoE 3/3 male volunteers (14GG, 29GT, and 8TT) were given a vitamin A fat-loading test consisting of 1 g of fat/kg body weight and 60,000 IU of vitamin A per m2 of body surface area. Blood samples were taken at time 0 and every hour until the sixth hour, and every 2 hours and 30 minutes until the eleventh hour. Cholesterol, triacylglycerols (TGs), and apoE were determined in plasma; and cholesterol, TG, apoB-100, apoB-48, and retinyl palmitate (RP) were analyzed in lipoprotein fractions. Postprandial lipemia data revealed that subjects with the −219TT genotype had a higher postprandial response of large TRL-cholesterol (P < 0.03), large TRL-triacylglycerols (P < 0.001), large TRL-RP (P < 0.004), and small TRL-apoB-48 (P < 0.03) than carriers of the −219G allele. Moreover, the −219TT subjects had the lowest postprandial levels of serum apoE (P < 0.05). In conclusion, the −219G/T polymorphism may influence TRL metabolism during the postprandial period, thus prolonging postprandial lipemia in subjects with the TT genotype. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | ASBMB | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Journal of Lipid Research 2003 Nov;44(11):2059-64. | es_ES |
dc.subject | Postprandial lipemia | es_ES |
dc.subject | Triacylglycerols | es_ES |
dc.subject | Retinyl palmitate | es_ES |
dc.subject | Cholesterol | es_ES |
dc.subject | Triacylglycerol-rich lipoproteins | es_ES |
dc.title | The influence of the apolipoprotein E gene promoter (-219G/T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1194/jlr.m300124-jlr200 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |