Listar Departamento de Biología Celular, Fisiología e Inmunología por título
Mostrando ítems 229-248 de 286
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Protective Role of Nrf2 in Renal Disease
(MDPI, 2020)Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. ... -
Proteomic profiling of adipose tissue from Zmpste24(-/-) Mice, a model of Lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing
(Science Direct, 2011)Lipodystrophy is a major disease involving severe alterations of adipose tissue distribution and metabolism. Mutations in genes encoding the nuclear envelope protein lamin A or its processing enzyme, the metalloproteinase ... -
PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing
(Springer Nature, 2023)Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing machinery components (spliceosome and splicing factors) and aberrant expression of oncogenic splice variants. We aimed to analyze the ... -
Quality of Life: Changes in Self-Perception in People with Down Syndrome as a Result of Being Part of a Football/Soccer Team. Self-Reports and External Reports
(MDPI, 2021)The hypothesis posed was whether being part of a football/soccer team influenced the quality of life (QL) of the people who participated in it since their perception of themselves is enhanced by factors, such as ... -
Rab18 drift in lipid droplet and endoplasmic reticulum interactions of adipocytes under obesogenic conditions
(MDPI, 2023)The adipose tissue stores excess energy in the form of neutral lipids within adipocyte lipid droplets (LDs). The correct function of LDs requires the interaction with other organelles, such as the endoplasmic reticulum ... -
Rab18 Dynamics in Adipocytes in Relation to Lipogenesis, Lipolysis and Obesity
(Public Libray of Science (PLOS), 2011)Lipid droplets (LDs) are organelles that coordinate lipid storage and mobilization, both processes being especially important in cells specialized in managing fat, the adipocytes. Proteomic analyses of LDs have consistently ... -
Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity
(PLOS, 2011)Lipid droplets (LDs) are organelles that coordinate lipid storage and mobilization, both processes being especially important in cells specialized in managing fat, the adipocytes. Proteomic analyses of LDs have consistently ... -
Rab18 is reduced in pituitary tumors cusing acromegaly and its overexpression reverts growth hormone hypersecretion
(Oxford Academic, 2008)Context: Rab proteins regulate the sequential steps of intracellular membrane transport. Alterations of these GTPases and their associated proteins are emerging as the underlying cause for several human diseases involving ... -
Regulación de la lisis de células de melanoma mediante coestimuladores y receptores inhibidores de la citotoxicidad
(Universidad de Córdoba, Servicio de Publicaciones, 2004)El sistema inmune a través de la inmunidad celular juega un papel importante en el reconocimiento y eliminación de células tumorales. La respuesta inmune celular requiere un reconocimiento específico del tumor seguido de ... -
Regulación de las gotas lipídicas en adipocitos: papel de RAB 18 y caracterización de su interactoma
(Universidad de Córdoba, Servicio de Publicaciones, 2014)El tejido adiposo (TA) juega un papel fundamental en la gestión de las reservas energéticas y como órgano endocrino productor de adipoquinas, que regulan la ingesta y la homeostasis energética, la inmunidad y la función ... -
Regulación fisiológica mitocondrial y de señalización autofágica a través de intervenciones nutricionales con diferentes fuentes lipídicas y antioxidantes
(Universidad de Córdoba, UCOPress, 2018)1. Introducción o motivación de la tesis La autofagia es un proceso intracelular por el que se degradan partes de citoplasma, orgánulos como mitocondrias y peroxisomas, agregados proteicos y agentes infecciosos, por acción ... -
Regulation of coenzyme Q biosynthesis through nutritional and pharmacological interventions
(Universidad de Córdoba, UCOPress, 2017)El coenzima Q (Q) es una benzoquinona prenilada presente en todos los organismos eucariotas. Se localiza principalmente en la mitocondria pero está presente en todas las membranas celulares. Esta molécula, además de ... -
Regulation of post-translational modifications with pharmacological intervention: autoimmune diseases and cancer
(Universidad de Córdoba, UCOPress, 2022)Post-Translational Modifications are key elements within the cell signalling pathways. These key events promptly reprogram protein's behaviour in presence of environmental alterations in a highly dynamic manner acting as ... -
Relaciones dentro de la subfamilia Papilionoideae a la luz de los datos palinológicos
(Universidad de Córdoba, Facultad de Ciencias, Departamento de Botánica; Asociación de Palinólogos de Lengua Española, 1985)En este t rabajo se realiza un análisis numérico de la semejanza pol ínica de 216 especies de Leguminosae de Andalucía Occi de ntal ~ dichas semejanzas se representan según un dendrograma y a partir del cual se comentan l ... -
Role and regulation of the novel splicing variants sst5TMD4 and In1-ghrelin in breast cancer
(Universidad de Córdoba, UCOPress, 2016)El cáncer, en sus múltiples formas, es uno de los mayores retos a los que se enfrenta la sociedad actual. Una de las mayores limitaciones en la investigación del cáncer es la gran heterogeneidad existente entre las diferentes ... -
Role of Endogenous Cortistatin in the Regulation of Ghrelin System Expression at Pancreatic Level under Normal and Obese Conditions
(Public Library Of Science (PLOS), 2013)Ghrelin-system components [native ghrelin, In1-ghrelin, Ghrelin-O-acyltransferase enzyme (GOAT) and receptors (GHS-Rs)] are expressed in a wide variety of tissues, including the pancreas, where they exert different ... -
Role of splicing process alterations in the appearance of endocrine-metabolic diseases and tumor pathologies
(Universidad de Córdoba, UCOPress, 2019)Global human health is currently threatened by highly prevalent diseases such as obesity, diabetes and cancer. A common hallmark shared by these endocrine-metabolic and tumor diseases is the consistent alteration of the ... -
Role of SST, CORT and ghrelin, and its receptors at the endocrine pancreas
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Role of Toll-like receptor 4 in intravascular hemolysis-mediated injury
(Wiley, 2022)Massive intravascular hemolysis is a common characteristic of several pathologies. It is associated with the release of large quantities of heme into the circulation, promoting injury in vulnerable organs, mainly kidney, ... -
Semaglutide improves liver steatosis and de novo lipogenesis markers in obese and type-2-diabetic mice with metabolic-dysfunction-associated steatotic liver disease
(MDPI, 2024)Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a prevalent clinical condition associated with elevated morbidity and mortality rates. Patients with MASLD treated with semaglutide, a glucagon-like ...