Listar Departamento de Biología Celular, Fisiología e Inmunología por título

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    • Somatostatin, cortistatin, ghrelin and their receptors: From an endocrine system to a pleiotropic system of pathophysiologic relevance 

      Gahete Ortiz, Manuel D. (Universidad de Córdoba, Servicio de Publicaciones, 2010)
      Somatostatina (SST)/cortistatina (CST) y ghrelina son los más conocidos miembros de dos sistemas complejos formados por un gran número de péptidos y receptores (ssts y GHS-Rs, respectivamente), que, aunque exhiben claras ...

    • Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing 

      López Cánovas, Juan Luis; Hermán Sánchez, Natalia; Moreno Montilla, M. Trinidad; Río Moreno, Mercedes del; Alors-Pérez, Emilia; Sánchez-Frías, Marina; Amado-Torres, Víctor; Ciria, Rubén; Briceño Delgado, Francisco Javier; Mata, Manuel de la; Castaño, Justo P.; Rodríguez-Perálvarez, Manuel; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Wiley, 2022)
      Introduction: Altered splicing landscape is an emerging cancer hallmark; however, the dysregulation and implication of the cellularmachinery controlling this process (spliceosome components and splicing factors) in ...

    • Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma 

      López Cánovas, Juan Luis; Río Moreno, Mercedes del; García Fernández, Helena; Jiménez-Vacas, J.M.; Moreno Montilla, M. Trinidad; Sánchez-Frías, Marina; Amado-Torres, Víctor; L-López, Fernando; Fernández Fondevila, Marcos; Ciria, Rubén; Gómez-Luque, Irene; Briceño Delgado, Francisco Javier; Nogueiras, Rubén; Mata, Manuel de la; Castaño, Justo P.; Rodríguez-Perálvarez, Manuel; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Elsevier, 2020)
      Splicing alterations represent an actionable cancer hallmark. Splicing factor 3B subunit 1 (SF3B1) is a crucial splicing factor that can be targeted pharmacologically (e.g. pladienolide-B). Here, we show that SF3B1 is ...

    • Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness Features 

      Vázquez Borrego, María del Carmen; Fuentes-Fayos, Antonio C.; Venegas-Moreno, Eva; Rivero-Cortés, Esther; Dios, Elena; Moreno Moreno, Paloma; Madrazo-Atutxa, Ainara; Remón, Pablo; Solivera, Juan; Wildemberg, Luiz E.; Kasuki, Leandro; López-Fernández, Judith M.; Gadelha, Mônica R.; Gálvez-Moreno, M. Ángeles; Soto-Moreno, Alfonso; Gahete Ortiz, Manuel D.; Castaño, Justo P.; Luque, Raúl M. (MDPI, 2019)
      Pituitary neuroendocrine tumors (PitNETs) constitute approximately 15% of all brain tumors, and most have a sporadic origin. Recent studies suggest that altered alternative splicing and, consequently, appearance of aberrant ...

    • Splicing Machinery Is Impaired in Oral Squamous Cell Carcinomas and Linked to Key Pathophysiological Features 

      Sanjuan-Sanjuan, Alba; Alors-Pérez, Emilia; Sánchez-Frías, Marina; Monserrat-Barbudo, José A.; Falguera Uceda, Mabel; Heredero-Jung, Susana; Luque, Raúl M. (MDPI, 2024)
      Alternative splicing dysregulation is an emerging cancer hallmark, potentially serving as a source of novel diagnostic, prognostic, or therapeutic tools. Inhibitors of the activity of the splicing machinery can exert ...

    • Subpoblaciones de células NK: cambios con la inmunosenescencia 

      López-Sejas, Nelson (Universidad de Córdoba, UCOPress, 2019)
      La inmunosenescencia se define como un deterioro progresivo de la función inmune asociada a la edad, este estado produce cambios que dan lugar a una remodelación del sistema inmunológico que afecta a la inmunidad innata y ...

    • Synergistic antibacterial effects of amoxicillin and gold nanoparticles: a therapeutic option to combat antibiotic resistance 

      Giráldez-Pérez, Rosa M.; Grueso, Elia; Carbonero, Alfonso; Álvarez Márquez, Juan; Gordillo, Miriam; Kuliszewska, Edyta; Prado-Gotor, Rafael (MDPI, 2023)
      Compacted Au@16-mph-16/DNA-AMOX (NSi) nanosystems were prepared from amoxicillin (AMOX) and precursor Au@16-mph-16 gold nanoparticles (Ni) using a Deoxyribonucleic acid (DNA) biopolymer as a glue. The synthesized nanocarrier ...

    • Terapia hormonal de GnRH y PGF2a en el puerperio del ganado vacuno de leche. I. Acción en el acortamiento del ciclo reproductivo 

      España España, F.; López-Sebastián, A.; Vivo-Rodríguez, R. (Universidad de Córdoba, Servicio de Publicaciones, 1992)
      Gonadotrophin releasing hormone (GnRH) analogue in combination with prostaglandin F2 alpha (PGF2a) was adiministered to VT in order to determine if it hastened the recovery of ovarian activity and uterine involution during ...

    • The Fusarium oxysporum gnt2, Encoding a Putative NAcetylglucosamine Transferase, Is Involved in Cell Wall Architecture and Virulence 

      López Fernández, Loida; Ruiz Roldán, Carmen; Pareja Jaime, Y.; Prieto, A.; Khraiwesh, Husam M.; González Roncero, M. Isabel (Public Library of Science, 2013)
      With the aim to decipher the molecular dialogue and cross talk between Fusarium oxysporum f.sp. lycopersci and its host during infection and to understand the molecular bases that govern fungal pathogenicity, we analysed ...

    • The ghrelin O-acyltransferase–ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes 

      Rodríguez, A; Gómez-Ambrosi, Javier; Catalán, Victoria; Rotellar, Fernando; Valentí, Víctor; Silva, Camilo; Mugueta, C.; Pulido, Marina R.; Vázquez, R.; Salvador, Javier; Malagón, María M.; Colina, I.; Frühbeck, Gema (SpringerLink, 2012)
      Aims/hypothesis Proinflammatory and proapoptotic cytokines such as TNF-α are upregulated in human obesity. We evaluated the association between ghrelin isoforms (acylated and desacyl ghrelin) and TNF-α in obesity and ...

    • The l-α-Lysophosphatidylinositol/GPR55 system and its potential role in human obesity 

      Moreno-Navarrete, José María; Catalán, Victoria; Whyte, Lauren; Díaz-Arteaga, Adenis; Vázquez-Martínez, Rafael; Rotellar, Fernando; Guzmán-Ruiz, Rocío; Gómez-Ambrosi, Javier; Pulido, Marina R.; Russell, Wendy R.; Imbernón, Mónica; Ross, Ruth A.; Malagón, María M.; Diéguez, Carlos; Fernández-Real, José Manuel; Frühbeck, Gema; Nogueiras, Rubén (American Diabetes Asociation, 2012)
      GPR55 is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. We investigated 1) whether GPR55 is expressed in fat and liver; 2) the correlation of both GPR55 and LPI ...

    • The Lin28/Let-7 System in Early Human Embryonic Tissue and Ectopic Pregnancy 

      Lozoya, Teresa; Domínguez, Francisco; Romero-Ruiz, Antonio; Steffani, Liliana; Martínez, Sebastián; Monterde, Mercedes; Ferri, Blanca; Núñez, María José; Romero- Espino, Ainoha; Zamora, Omar; Gurrea, Marta; Sangiao-Alvarellos, Susana; Vega, Olivia; Simón, Carlos; Pellicer, Antonio; Tena-Sempere, Manuel (PLOS, 2014)
      Our objective was to determine the expression of the elements of the Lin28/Let-7 system, and related microRNAs (miRNAs), in early stages of human placentation and ectopic pregnancy, as a means to assess the potential role ...

    • The potential role of the adipokine HMGB1 in obesity and insulin resistance. Novel effects on adipose tissue biology 

      Guzmán Ruiz, R.; Tercero-Alcázar, C.; López-Alcalá, J.; Sánchez Ceinos, Julia; Malagón, María M.; Gordon, Ana (Elsevier, 2021)
      Discovery of the adipose tissue as a major source of signaling molecules almost three decades ago set a novel physiological paradigm that paved the way for the identification of metabolic organs as endocrine organs. ...

    • The protective effect of extra-virgin olive oil in the experimental model of multiple sclerosis in the rat 

      Conde, Cristina; Escribano, Begoña M.; Luque, Evelio; Aguilar-Luque, Macarena; Feijoo, Marisa; Ochoa, J.J.; Latorre, Manuel; Giraldo, Ana I.; Lillo, Rafael; Agüera Carmona, Eduardo; Santamaría, Abel; Túnez, Isaac (Taylor & Francis, 2018)
      This study has evaluated the effect of EVOO (Extra-Virgin olive oil), OA (oleic acid) and HT (hydroxytyrosol) in an induced model of MS through experimental autoimmune encephalomyelitis (EAE). Dark Agouti 2-month old ...

    • The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health 

      Clemente-Postigo, Mercedes; Tinahones, Alberto; Bekay, Rajaa El; Malagón, María M.; Tinahones, Francisco J. (MDPI, 2020)
      White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT ...

    • The Somatostatin Analogue Octreotide Inhibits Growth of Small Intestine Neuroendocrine Tumour Cells 

      Li, Su-Chen; Martijn, Cécile; Cui, Tao; Essaghir, Ahmed; Luque, Raúl M.; Demoulin, Jean-Baptiste; Castaño, Justo P.; Öberg, Kjell; Giandomenico, Valeria (Public Library Of Science (PLOS), 2012)
      Octreotide is a widely used synthetic somatostatin analogue that significantly improves the management of neuroendocrine tumours (NETs). Octreotide acts through somatostatin receptors (SSTRs). However, the molecular mechanisms ...

    • The somatostatin/cortistatin/neuronostatin system and RNA-exosome complex as novel sources for the identification of useful diagnostic, prognostic and therapeutic tools in prostate cancer 

      Sáez Martínez, Prudencio (Universidad de Córdoba, UCOPress, 2024)
      El cáncer de próstata (CaP) es una de las patologías tumorales más relevantes para el sistema sanitario, ya que cada año se registran 1.3 millones de nuevos casos y 400,000 muertes asociadas en todo el mundo. Los abordajes ...

    • The stromal-vascular fraction of adipose tissue contributes to major differences between subcutaneous and visceral fat depots 

      Peinado, Juan R.; Jiménez Gómez, Yolanda; Pulido, Marina R.; Ortega-Bellido, María; Díaz-López, César; Padillo, Francisco; López Miranda, José; Vazquez-Martínez, Rafael; Malagón, María M. (Wiley, 2010)
      Adipose tissue represents a complex tissue both in terms of its cellular composition, as it includes mature adipocytes and the various cell types comprising the stromal-vascular fraction (SVF), and in relation to the ...

    • Therapeutic Potential and Immunomodulatory Role of Coenzyme Q10 and Its Analogues in Systemic Autoimmune Diseases 

      López-Pedrera, Ch.; Villalba, José Manuel; Patiño-Trives, Alejandra Mª; Luque-Tévar, María; Barbarroja, Nuria; Aguirre, M.A.; Escudero Contreras, Alejandro; Pérez Sánchez, Carlos (MDPI, 2021)
      Coenzyme Q10 (CoQ10) is a mitochondrial electron carrier and a powerful lipophilic antioxidant located in membranes and plasma lipoproteins. CoQ10 is endogenously synthesized and obtained from the diet, which has raised ...

    • Tipos hemoglobínicos en équidos 

      Garzón Garrido-Espiga, R.; Zarazaga Burillo, Isaías; Vallejo Vicente, M.; Castejón Montijano, F.; Rodero Franganillo, Antonio (Universidad de Córdoba, Servicio de Publicaciones, 1978)
      Horses of the english, the spanish•and the arabian thoroitg bred, had been studied conceming the haernoglobinic polyrnorphism. The geneic and genotype frecuencyes are expressed, having found significant differences between ...