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Mostrando ítems 261-270 de 290
Influencia de la alimentación con forrajes con alta carga de micotoxinas en parámetros fisiológicos de bienestar animal y lesiones orgánicas en ovinos
(RACVAO, 2017)
La obtención de forrajes en verano como el maíz tiene el gran problema de que puede conllevar una alta carga de micotoxinas, producidas en el crecimiento del forraje por hongos, y que al emplearse en vacuno lechero, pueden ...
Identification of immunosenescence markers in models of cardiovascular disease, infection, and inflammatory-based diseases
(Universidad de Córdoba, UCOPress, 2024)
The immune system, a complex defense system, safeguards the body from various threats. Immunosenescence, an age-related deterioration of the immune system, is characterized by the accumulation of memory T cells and the ...
The somatostatin/cortistatin/neuronostatin system and RNA-exosome complex as novel sources for the identification of useful diagnostic, prognostic and therapeutic tools in prostate cancer
(Universidad de Córdoba, UCOPress, 2024)
El cáncer de próstata (CaP) es una de las patologías tumorales más relevantes para el sistema sanitario, ya que cada año se registran 1.3 millones de nuevos casos y 400,000 muertes asociadas en todo el mundo. Los abordajes ...
Welfare Quality® for dairy cows: towards a sensor-based assessment
(Cambridge University Press, 2020)
This Research Reflection addresses the possibilities for Welfare Quality® to evolve from an assessment method based on data gathered on punctual visits to the farm to an assessment method based on sensor data. This approach ...
Estudio sobre la fisiología aplicada del bienestar animal del ganado ovino alimentado a base de nuevos cereales (Tritordeum y DDRR) frente a cereales tradicionales
(Universidad de Córdoba, UCOPress, 2024)
Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer
(Wiley, 2023)
S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme that has been suggested to play a tumor suppressor role, although the mechanisms responsible are still largely unclear. In this study, we show that GSNOR ...
Journal article resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways
(Endocrine Society, 2009)
The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function. Although adipose tissue is the primary source of resistin, it is also ...
Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma
(Elsevier, 2020)
Splicing alterations represent an actionable cancer hallmark. Splicing factor 3B subunit 1 (SF3B1) is a crucial splicing factor that can be targeted pharmacologically (e.g. pladienolide-B). Here, we show that SF3B1 is ...
Peptides derived from the extracellular domain of the somatostatin receptor splicing variant 1 SST5TMD4 increase malignancy in multiple cancer cell types
(Elsevier, 2019)
Extracellular fragments derived from plasma membrane receptors can play relevant roles in the development/progression of tumor pathologies, thereby offering novel diagnostic or therapeutic opportunities. The truncated ...
Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing
(Wiley, 2022)
Introduction: Altered splicing landscape is an emerging cancer hallmark; however, the dysregulation and implication of the cellularmachinery controlling this process (spliceosome components and splicing factors) in ...