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Metabolic Impact of Adult-Onset, Isolated, Growth Hormone Deficiency (AOiGHD) Due to Destruction of Pituitary Somatotropes
(Public Library Of Science (PLOS), 2011)
Growth hormone (GH) inhibits fat accumulation and promotes protein accretion, therefore the fall in GH observed with weight
gain and normal aging may contribute to metabolic dysfunction. To directly test this hypothesis ...
Contribution of somatostatin, cortistatin, their receptors and other peptides to the regulation of growth hormone in primates and mice
(Universidad de Córdoba, Servicio de Publicaciones, 2011)
La regulación de la secreción de hormona del crecimiento (GH) se ha considerado clásicamente como resultado de la acción conjunta y coordinada de dos péptidos hipotalámicos: la hormona liberadora de GH (GHRH) y el factor ...
A Novel Human Ghrelin Variant (In1-Ghrelin) and Ghrelin-O-Acyltransferase Are Overexpressed in Breast Cancer: Potential Pathophysiological Relevance
(Public Library Of Science (PLOS), 2011)
The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a
117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a ...
Role of Endogenous Cortistatin in the Regulation of Ghrelin System Expression at Pancreatic Level under Normal and Obese Conditions
(Public Library Of Science (PLOS), 2013)
Ghrelin-system components [native ghrelin, In1-ghrelin, Ghrelin-O-acyltransferase enzyme (GOAT) and receptors (GHS-Rs)]
are expressed in a wide variety of tissues, including the pancreas, where they exert different ...