ListarDepartamento de Genética por tema "Arabidopsis"
Mostrando ítems 1-4 de 4
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A discontinuous DNA glycosylase domain in a family of enzymes that excise 5-methylcytosine
(Oxford University Press, 2011)DNA cytosine methylation (5-meC) is a widespread epigenetic mark associated to gene silencing. In plants, DEMETER-LIKE (DML) proteins typified by Arabidopsis REPRESSOR OF SILENCING 1 (ROS1) initiate active DNA demethylation ... -
Complementary Functions of Plant AP Endonucleases and AP Lyases during DNA Repair of Abasic Sites Arising from C:G Base Pairs
(MDPI, 2021)Abasic (apurinic/apyrimidinic, AP) sites are ubiquitous DNA lesions arising from spontaneous base loss and excision of damaged bases. They may be processed either by AP endonucleases or AP lyases, but the relative roles ... -
ROS1 5-methylcytosine DNA glycosylase is a slow-turnover catalyst that initiates DNA demethylation in a distributive fashion
(Oxford University Press, 2009)Arabidopsis ROS1 belongs to a family of plant 5-methycytosine DNA glycosylases that initiate DNA demethylation through base excision. ROS1 displays the remarkable capacity to excise 5-meC, and to a lesser extent T, ... -
The DNA Repair Protein XRCC1 Functions in the Plant DNA Demethylation Pathway by Stimulating Cytosine Methylation (5-meC) Excision, Gap Tailoring, and DNA Ligation
(JBC, 2013)Background: Active DNA demethylation in plants is initiated by 5-meC DNA glycosylases of the ROS1/DME family and continued through a base excision repair pathway. Results: XRCC1 stimulates ROS1-initiated demethylation ...