ListarDepartamento de Genética por tema "Epigenetics"

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    • A DNA 3′ Phosphatase Functions in Active DNA Demethylation in Arabidopsis 

      Martínez-Macías, M.I.; Qian, Weiqiang; Miki, Daisuke; Pontes, Olga; Liu, Yunhua; Tang, Kai; Liu, Renyi; Morales-Ruiz, T.; Ariza, Rafael R.; Roldán-Arjona, Teresa; Zhu, Jian-Kang (Cell Press, 2012)
      DNA methylation is an important epigenetic mark established by the combined actions of methylation and demethylation reactions. Plants use a base excision repair pathway for active DNA demethylation. After 5-methylcytosine ...

    • Active DNA demethylation in plants 

      Parrilla-Doblas, Jara; Roldán-Arjona, Teresa; Ariza, Rafael R.; Córdoba-Cañero, Dolores (MDPI, 2019)
      Methylation of cytosine (5-meC) is a critical epigenetic modification in many eukaryotes, and genomic DNA methylation landscapes are dynamically regulated by opposed methylation and demethylation processes. Plants are ...

    • DNA methylation editing by CRISPR-guided excision of 5-methylcytosine 

      Devesa-Guerra, I.; Morales-Ruiz, T.; Pérez Roldán, Juan; Parrilla-Doblas, Jara; Dorado León, Macarena; García-Ortiz, M.V.; Ariza, Rafael R.; Roldán-Arjona, Teresa (Elsevier, 2020)
      Tools for active targeted DNA demethylation are required to increase our knowledge about regulation and specific functions of this important epigenetic modification. DNA demethylation in mammals involve TET-mediated oxidation ...

    • The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity. DNA Repair 

      Parrilla-Doblas, Jara; Morales-Ruiz, T.; Ariza, Rafael R.; Martínez-Macías, M.I.; Roldán-Arjona, Teresa (Elsevier, 2022)
      La desmetilación activa del ADN desempeña un papel importante en el control de los patrones de metilación en los eucariotas. En las plantas, la familia DEMETER-LIKE (DML) de 5-metilcitosina ADN glicosilasas inicia la ...