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Astaxanthin from Haematococcus pluvialis Prevents Oxidative Stress on Human Endothelial Cells without Toxicity

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Author
Régnier, Philippe
Bastias, Jorge
Rodríguez-Ruiz, Violeta
Caballero-Casero, Noelia
Caballo Linares, Carmen
Sicilia Criado, María Dolores
Fuentes, Axelle
Maire, Murielle
Crepin, Michel
Letourneur, Didier
Gueguen, Virginie
Rubio Bravo, Soledad
Pavon-Djavid, Graciela
Publisher
MDPI
Date
2015
Subject
Astaxanthin
Antioxidants
Haematococcus pluvialis
Oxidative stress
HUVEC
TEAC
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Abstract
Astaxanthin, a powerful antioxidant, is a good candidate for the prevention of intracellular oxidative stress. The aim of the study was to compare the antioxidant activity of astaxanthin present in two natural extracts from Haematococcus pluvialis, a microalgae strain, with that of synthetic astaxanthin. Natural extracts were obtained either by solvent or supercritical extraction methods. UV, HPLC-DAD and (HPLC-(atmospheric pressure chemical ionization (APCI)+)/ion trap-MS) characterizations of both natural extracts showed similar compositions of carotenoids, but different percentages in free astaxanthin and its ester derivatives. The Trolox equivalent antioxidant capacity (TEAC) assay showed that natural extracts containing esters displayed stronger antioxidant activities than free astaxanthin. Their antioxidant capacities to inhibit intracellular oxidative stress were then evaluated on HUVEC cells. The intracellular antioxidant activity in natural extracts was approximately 90-times higher than synthetic astaxanthin (5 μM). No modification, neither in the morphology nor in the viability, of vascular human cells was observed by in vitro biocompatibility study up to 10 μM astaxanthin concentrations. Therefore, these results revealed the therapeutic potential of the natural extracts in vascular human cell protection against oxidative stress without toxicity, which could be exploited in prevention and/or treatment of cardiovascular diseases
URI
http://hdl.handle.net/10396/15395
Fuente
Marine Drugs 13(5), 2857-2874 (2015)
Versión del Editor
http://dx.doi.org/10.3390/md13052857
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