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Effect of Cytomegalovirus (CMV) and Ageing on T-Bet and Eomes Expression on T-Cell Subsets
dc.contributor.author | Hassouneh, Fakhri | |
dc.contributor.author | López-Sejas, Nelson | |
dc.contributor.author | Sánchez-Correa, Beatriz | |
dc.contributor.author | Tarazona, Raquel | |
dc.contributor.author | Solana Lara, Rafael | |
dc.contributor.author | Pera Rojas, Alejandra | |
dc.contributor.author | Campos Fernández, Carmen | |
dc.date.accessioned | 2017-11-20T10:58:26Z | |
dc.date.available | 2017-11-20T10:58:26Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | http://hdl.handle.net/10396/15477 | |
dc.description.abstract | The differential impact of ageing and cytomegalovirus (CMV) latent infection on human T-cell subsets remains to some extent controversial. The purpose of this study was to analyse the expression of the transcription factors T-bet and Eomes and CD57 on CD4+, CD4hiCD8lo and CD8+ T-cell subsets in healthy individuals, stratified by age and CMV serostatus. The percentage of CD4+ T-cells expressing T-bet or Eomes was very low, in particular in CD4+ T-cells from young CMV-seronegative individuals, and were higher in CMV-seropositive older individuals, in both CD57− and CD57+ CD4+ T-cells. The study of the minor peripheral blood double-positive CD4hiCD8lo T-cells showed that the percentage of these T-cells expressing both Eomes and T-bet was higher compared to CD4+ T-cells. The percentage of CD4hiCD8lo T-cells expressing T-bet was also associated with CMV seropositivity and the coexpression of Eomes, T-bet and CD57 on CD4hiCD8lo T-cells was only observed in CMV-seropositive donors, supporting the hypothesis that these cells are mature effector memory cells. The percentage of T-cells expressing Eomes and T-bet was higher in CD8+ T-cells than in CD4+ T-cells. The percentages of CD8+ T-cells expressing Eomes and T-bet increased with age in CMV-seronegative and -seropositive individuals and the percentages of CD57− CD8+ and CD57+ CD8+ T-cells coexpressing both transcription factors were similar in the different groups studied. These results support that CMV chronic infection and/or ageing are associated to the expansion of highly differentiated CD4+, CD4hiCD8lo and CD8+ T-cells that differentially express T-bet and Eomes suggesting that the expression of these transcription factors is essential for the generation and development of an effector-memory and effector T lymphocytes involved in conferring protection against chronic CMV infection. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | International Journal of Moecular Science 18(7), 1391 (2017) | es_ES |
dc.subject | Ageing | es_ES |
dc.subject | Cytomegalovirus (CMV) | es_ES |
dc.subject | CD57 | es_ES |
dc.subject | Eomes | es_ES |
dc.subject | T-bet | es_ES |
dc.subject | T-cells | es_ES |
dc.title | Effect of Cytomegalovirus (CMV) and Ageing on T-Bet and Eomes Expression on T-Cell Subsets | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3390/ijms18071391 | es_ES |
dc.relation.projectID | Gobierno de España. SAF2013-46161-R | es_ES |
dc.relation.projectID | Instituto de Salud Carlos III. PI13/02691 | es_ES |
dc.relation.projectID | Instituto de Salud Carlos III. PI16/01615 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |