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dc.contributor.authorHerrera-Martínez, Aura D.
dc.contributor.authorGahete Ortiz, Manuel D.
dc.contributor.authorSánchez-Sánchez, Rafael
dc.contributor.authorAlors-Pérez, Emilia
dc.contributor.authorPedraza-Arévalo, Sergio
dc.contributor.authorSerrano-Blanch, Raquel
dc.contributor.authorMartínez-Fuentes, Antonio J.
dc.contributor.authorCastaño, Justo P.
dc.contributor.authorLuque, Raúl M.
dc.contributor.authorGálvez-Moreno, M. Ángeleses_ES
dc.date.accessioned2018-10-15T07:58:33Z
dc.date.available2018-10-15T07:58:33Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10396/17260
dc.description.abstractObjectives: The association between the presence and alterations of the components of the ghrelin system and the development and progression of neuroendocrine tumors (NETs) is still controversial and remains unclear. Methods: Here, we systematically evaluated the expression levels (by quantitative-PCR) of key ghrelin system components of in gastroenteropancreatic (GEP)-NETs, as compared to non-tumor adjacent (NTA; n = 42) and normal tissues (NT; n = 14). Then, we analyzed their putative associations with clinical-histological characteristics. Results: The results indicate that ghrelin and its receptor GHSR1a are present in a high proportion of normal tissues, while the enzyme ghrelin-O-acyltransferase (GOAT) and the splicing variants In1-ghrelin and GHSR1b were present in a lower proportion of normal tissues. In contrast, all ghrelin system components were present in a high proportion of tumor and NTA tissues. GOAT was significantly overexpressed (by quantitative-PCR (qPCR)) in tumor samples compared to NTA, while a trend was found for ghrelin, In1-ghrelin and GHSR1a. In addition, expression of these components displayed significant correlations with key clinical parameters. The marked overexpression of GOAT in tumor samples compared to NTA regions was confirmed by IHC, revealing that this enzyme is particularly overexpressed in gastrointestinal NETs, where it is directly correlated with tumor diameter. Conclusions: These results provide novel information on the presence and potential pathophysiological implications of the ghrelin system components in GEP-NETs, wherein GOAT might represent a novel diagnostic biomarker.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherNature.comes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceClinical and Translational Gastroenterology 9(10):196 (2018)es_ES
dc.subjectNeuroendocrine tumorses_ES
dc.subjectBiomarkerses_ES
dc.subjectEnzymeses_ES
dc.titleGhrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumorses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1038/s41424-018-0058-8es_ES
dc.relation.projectIDJunta de Andalucía. BIO- 0139es_ES
dc.relation.projectIDJunta de Andalucía. CTS-1406es_ES
dc.relation.projectIDJunta de Andalucía. PI-0077-2016es_ES
dc.relation.projectIDGobierno de España. BFU2016-80360-Res_ES
dc.relation.projectIDGobierno de España. PI16/ 00264es_ES
dc.relation.projectIDGobierno de España. FI17/00282es_ES
dc.relation.projectIDGobierno de España. CP15/00156es_ES
dc.relation.projectIDGobierno de España. FPU2014/04290es_ES
dc.relation.projectIDGobierno de España. CIBERes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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