Recent Advances in Liquid Biopsy in Patients With Castration Resistant Prostate Cancer
Author
Di Nunno, Vincenzo
Gatto, Lidia
Santoni, Matteo
Cimadamore, Alessia
López-Beltrán, Antonio
Cheng, Liang
Scarpelli, Marina
Montironi, Rodolfo
Massari, Francesco
Publisher
FrontiersDate
2018Subject
Prostate cancerMetastatic castration resistant prostate cancer
CTCs
Liquid biopsy
Circulating DNA
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Show full item recordAbstract
Management of localized and advanced prostate cancer benefits from several
therapeutic options with a surprising improvement in terms of clinical outcome. The
selection of patients more likely to benefit from a specific approach still remains a key
issue as well as the early identification of patients with aggressive disease which could
benefit from a more aggressive treatment strategy. The lack of reliable bio-marker in
castration resistant setting able to monitor response to treatment and early inform about
tumor progression is an emerging issue. Accordingly, circulating DNA and circulating
tumor cells appears a promising and attractive approach despite to date practical
applications of these techniques are few and not validated. The aim of this review of
the literature is to explore current knowledge on liquid biopsy in prostate cancer focusing
on possible future applications.