Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses
Autor
Appel, Kurt
Muñoz, Eduardo
Navarrete, Carmen
Cruz Teno, Cristina
Biller, Andreas
Thiemann, Eva
Editor
MDPIFecha
2018Materia
AllergyInflammation
Mast cells
Immulina®
ImmunLoges
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Immulina®, a high-molecular-weight polysaccharide extract from the cyanobacterium
Arthrospira platensis (Spirulina) is a potent activator of innate immune cells. On the other hand, it is
well documented that Spirulina exerts anti-inflammatory effects and showed promising effects with
respect to the relief of allergic rhinitis symptoms. Taking into account these findings, we decided
to elucidate whether Immulina®, and immunLoges® (a commercial available multicomponent
nutraceutical with Immulina® as a main ingredient) beyond immune-enhancing effects, might also
exert inhibitory effects in the induced allergic inflammatory response and on histamine release from
RBL-2H3 mast cells. Our findings show that Immulina® and immunLoges® inhibited the IgE-antigen
complex-induced production of TNF- , IL-4, leukotrienes and histamine. The compound 48/80
stimulated histamine release in RBL-2H3 cells was also inhibited. Taken together, our results showed
that Immulina® and immunLoges® exhibit anti-inflammatory properties and inhibited the release
of histamine from mast cells.