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dc.contributor.authorRodriguez-Ruiz, Violeta
dc.contributor.authorSalatti Dorado, José Ángel
dc.contributor.authorBarzegari, Abolfazl
dc.contributor.authorNicolas-Boluda, Alba
dc.contributor.authorHouaoui, Amel
dc.contributor.authorCaballo Linares, Carmen
dc.contributor.authorCaballero-Casero, Noelia
dc.contributor.authorSicilia Criado, María Dolores
dc.contributor.authorBastias Venegas, Jorge
dc.contributor.authorPauthe, Emmanuel
dc.contributor.authorOmidi, Yadollah
dc.contributor.authorLetourneur, Didier
dc.contributor.authorGueguen, Virginie
dc.contributor.authorPavon-Djavid, Graciela
dc.contributor.authorRubio Bravo, Soledades_ES
dc.date.accessioned2018-11-02T09:23:12Z
dc.date.available2018-11-02T09:23:12Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10396/17394
dc.description.abstractAstaxanthin is a xanthophyll carotenoid showing efficient scavenging ability and represents an interesting candidate in the development of new therapies for preventing and treating oxidative stress-related pathologies. However, its high lipophilicity and thermolability often limits its antioxidant efficacy in human applications. Here, we developed a formulation of lipid carriers to protect astaxanthin’s antioxidant activity. The synthesis of natural astaxanthin-loaded nanostructured lipid carriers using a green process with sunflower oil as liquid lipid is presented. Their antioxidant activity was measured by -Tocopherol Equivalent Antioxidant Capacity assay and was compared to those of both natural astaxanthin and -tocopherol. Characterizations by dynamic light scattering, atomic force microscopy, and scattering electron microscopy techniques were carried out and showed spherical and surface negative charged particles with z-average and polydispersity values of ~60 nm and ~0.3, respectively. Astaxanthin loading was also investigated showing an astaxanthin recovery of more than 90% after synthesis of nanostructured lipid carriers. These results demonstrate the capability of the formulation to stabilize astaxanthin molecule and preserve and enhance the antioxidant activityes_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceMolecules 23, 2601 (2018)es_ES
dc.subjectAstaxanthines_ES
dc.subjectNanostructured lipid carrierses_ES
dc.subjectAntioxidantses_ES
dc.subjectHaematoccocus pluvialises_ES
dc.subjectLipophilic ABTS assayes_ES
dc.titleAstaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/molecules23102601es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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