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Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis
dc.contributor.author | Esteras, Raquel | |
dc.contributor.author | Fox, Jonathan G. | |
dc.contributor.author | Geddes, Colin C. | |
dc.contributor.author | Mackinnon, Bruce | |
dc.contributor.author | Ortiz, Alberto | |
dc.contributor.author | Moreno, Juan Antonio | |
dc.date.accessioned | 2020-07-07T19:32:18Z | |
dc.date.available | 2020-07-07T19:32:18Z | |
dc.date.issued | 2020 | |
dc.identifier.uri | http://hdl.handle.net/10396/20297 | |
dc.description.abstract | Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury. Although haematuria is a risk factor for the development of renal disease, no previous study has analyzed the significance of haematuria in ATIN. Retrospective, observational analysis of 110 patients with biopsy-proven ATIN was conducted. Results: Haematuria was present in 66 (60%) ATIN patients. A higher percentage of ATIN patients with haematuria had proteinuria than patients without haematuria (89.4% vs. 59.1%, p = 0.001) with significantly higher levels of proteinuria (median (interquartile range) protein:creatinine ratio 902.70 (513–1492) vs. 341.00 (177–734) mg/g, p <0.001). Moreover, those patients with more haematuria intensity had a higher urinary protein:creatinine ratio (1352.65 (665–2292) vs. 849.60 (562–1155) mg/g, p = 0.02). Those patients with higher proteinuria were more likely to need renal replacement therapy (22.7 vs. 0%, p = 0.03) and to suffer relapse (4 vs. 0%, p = 0.03). At the end of follow up, haematuric ATIN patients had higher serum creatinine levels (3.19 ± 2.91 vs. 1.91 ± 1.17 mg/dL, p = 0.007), and a trend towards a higher need for acute dialysis (7 vs. 1%, p = 0.09) and renal replacement therapy (12.1 vs. 2.3%, p = 0.12). Haematuria is common in ATIN and it is associated with worse renal function outcomes. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Journal of Clinical Medicine 9(7), 2135 (2020) | es_ES |
dc.subject | Acute kidney injury | es_ES |
dc.subject | Acute tubulointerstitial nephritis | es_ES |
dc.subject | Haematuria | es_ES |
dc.subject | Kidney biopsy | es_ES |
dc.subject | Outcomes | es_ES |
dc.subject | Proteinuria | es_ES |
dc.subject | Chronic kidney disease | es_ES |
dc.title | Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3390/jcm9072135 | es_ES |
dc.relation.projectID | Instituto de Salud Carlos III. PI17/00130 | es_ES |
dc.relation.projectID | Instituto de Salud Carlos III. PI19/00815 | es_ES |
dc.relation.projectID | Gobierno de España. RYC-2017-22369 | es_ES |
dc.relation.projectID | Gobierno de España. DTS18/00032 | es_ES |
dc.relation.projectID | Instituto de Salud Carlos III. RD016/0009 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |