Listar DGen-Artículos, capítulos... por autor "e7725780-5575-4c33-9586-ee15c74d52b0"
Mostrando ítems 1-6 de 6
-
Active DNA demethylation in plants
Parrilla-Doblas, Jara; Roldán-Arjona, Teresa; Ariza, Rafael R.; Córdoba-Cañero, Dolores (MDPI, 2019)Methylation of cytosine (5-meC) is a critical epigenetic modification in many eukaryotes, and genomic DNA methylation landscapes are dynamically regulated by opposed methylation and demethylation processes. Plants are ... -
DNA methylation editing by CRISPR-guided excision of 5-methylcytosine
Devesa-Guerra, I.; Morales-Ruiz, T.; Pérez Roldán, Juan; Parrilla-Doblas, Jara; Dorado León, Macarena; García-Ortiz, M.V.; Ariza, Rafael R.; Roldán-Arjona, Teresa (Elsevier, 2020)Tools for active targeted DNA demethylation are required to increase our knowledge about regulation and specific functions of this important epigenetic modification. DNA demethylation in mammals involve TET-mediated oxidation ... -
DNA Methylation Editing by CRISPR-guided Excision of 5-Methylcytosine
Devesa-Guerra, I.; Morales-Ruiz, T.; Pérez Roldán, Juan; Parrilla-Doblas, Jara; Dorado León, Macarena; García-Ortiz, M.V.; Ariza, Rafael R.; Roldán-Arjona, Teresa (Elsevier, 2020)Las herramientas para la desmetilación activa y dirigida del ADN son esenciales para poder entender la regulación y funciones específicas de esta importante modificación epigenética. La desmetilación del ADN en mamíferos ... -
Early steps of active DNA demethylation initiated by ROS1 glycosylase require three putative helix-invading residues
Parrilla-Doblas, Jara; Ponferrada-Marín, María Isabel; Roldán-Arjona, Teresa; Rodríguez Ariza, Rafael (Oxford University Press, 2013)Active DNA demethylation is crucial for epigenetic control, but the underlying enzymatic mechanisms are incompletely understood. REPRESSOR OF SILENCING 1 (ROS1) is a 5-methylcytosine (5-meC) DNA glycosylase/lyase that ... -
Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosineDNA glycosylase to a sequence-specific DNA binding domain
Parrilla-Doblas, Jara; Ariza, Rafael R.; Roldán-Arjona, Teresa (Taylor & Francis, 2017)DNA methylation is a crucial epigenetic mark associated to gene silencing, and its targeted removal is amajor goal of epigenetic editing. In animal cells, DNA demethylation involves iterative 5mC oxidation byTET enzymes ... -
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity. DNA Repair
Parrilla-Doblas, Jara; Morales-Ruiz, T.; Ariza, Rafael R.; Martínez-Macías, M.I.; Roldán-Arjona, Teresa (Elsevier, 2022)La desmetilación activa del ADN desempeña un papel importante en el control de los patrones de metilación en los eucariotas. En las plantas, la familia DEMETER-LIKE (DML) de 5-metilcitosina ADN glicosilasas inicia la ...