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dc.contributor.authorBrodzki, Adam
dc.contributor.authorŁopuszynski, Wojciech
dc.contributor.authorMillán, Yolanda
dc.contributor.authorTatara, Marcin R.
dc.contributor.authorBrodzki, Piotr
dc.contributor.authorKulpa, Katarzyna
dc.contributor.authorMinakow, Natalia
dc.date.accessioned2021-03-19T12:53:52Z
dc.date.available2021-03-19T12:53:52Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10396/21214
dc.description.abstractPerianal gland tumors are modified sebaceous glands present in the skin of the perianal region in the dog. Hormonal stimulation may induce hyperplasia of the perianal glands or their neoplastic progression. The presence of androgen (AR) and estrogen (ER) receptors have been demonstrated both in normal perianal glands as well as in perianal tumors. The aim of the study was an immunohistochemical assessment of the expression of estrogen and androgen receptors in perianal gland tumors in dogs as an applicatory marker for antihormonal treatment. Biopsy samples of perianal masses were collected from 41 male dogs. A histopathological examination revealed 24 adenomas, 12 epitheliomas and five carcinomas. The immunohistochemical staining showed a mainly nuclear expression of AR and ER in the neoplastic cells. Both the androgen and estrogen receptors were expressed in adenoma, epithelioma and carcinoma cases; however, the highest expression of the receptors was stated in the adenoma and epithelioma. In the case of the carcinoma, the expression of sex hormone receptors was very weak. The differences of the number of cells expressing AR and ER as well as the observed differentiated intensity of staining in the studies demonstrated that the determination of the expression of the sex hormone receptors may be useful to elaborate a diagnostic and therapeutic algorithm.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceAnimals 11(3), 875 (2021)es_ES
dc.subjectPerianal gland tumorses_ES
dc.subjectMale dogses_ES
dc.subjectEstrogen receptores_ES
dc.subjectAndrogen receptores_ES
dc.subjectImmunohistochemistryes_ES
dc.titleAndrogen and Estrogen Receptor Expression in Different Types of Perianal Gland Tumors in Male Dogses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/ani11030875es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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