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The Potassium Transporter Hak1 in Candida Albicans, Regulation and Physiological Effects at Limiting Potassium and under Acidic Conditions
dc.contributor.author | Ruiz-Castilla, Francisco J. | |
dc.contributor.author | Rodríguez-Castro, Elisa | |
dc.contributor.author | Michán, Carmen | |
dc.contributor.author | Ramos, José | |
dc.date.accessioned | 2021-05-07T06:28:13Z | |
dc.date.available | 2021-05-07T06:28:13Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://hdl.handle.net/10396/21336 | |
dc.description.abstract | The three families of yeast plasma membrane potassium influx transporters are represented in Candida albicans: Trk, Acu, and Hak proteins. Hak transporters work as K+-H+ symporters, and the genes coding for Hak proteins are transcriptionally activated under potassium limitation. This work shows that C. albicans mutant cells lacking CaHAK1 display a severe growth impairment at limiting potassium concentrations under acidic conditions. This is the consequence of a defective capacity to transport K+, as indicated by potassium absorption experiments and by the kinetics parameters of Rb+ (K+) transport. Moreover, hak1− cells are more sensitive to the toxic cation lithium. All these phenotypes became much less robust or even disappeared at alkaline growth conditions. Finally, transcriptional studies demonstrate that the hak1− mutant, in comparison with HAK1+ cells, activates the expression of the K+/Na+ ATPase coded by CaACU1 in the presence of Na+ or in the absence of K+. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Journal of Fungi 7(5), 362 (2021) | es_ES |
dc.subject | Candida albicans | es_ES |
dc.subject | Potassium transporters | es_ES |
dc.subject | Hak1 | es_ES |
dc.subject | Lithium | es_ES |
dc.subject | pH | es_ES |
dc.title | The Potassium Transporter Hak1 in Candida Albicans, Regulation and Physiological Effects at Limiting Potassium and under Acidic Conditions | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3390/jof7050362 | es_ES |
dc.relation.projectID | Gobierno de España. RTI2018-097935-B-I00 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |