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Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Withdrawal Is Associated with Higher Mortality in Hospitalized Patients with COVID-19
dc.contributor.author | Roy Vallejo, Emilia | |
dc.contributor.author | Sánchez Purificación, Aquilino | |
dc.contributor.author | Torres‑Peña, J.D. | |
dc.contributor.author | Sánchez Moreno, Beatriz | |
dc.contributor.author | Arnalich-Fernández, Francisco | |
dc.contributor.author | García Blanco, María José | |
dc.contributor.author | López-Miranda, José | |
dc.contributor.author | Romero-Cabrera, Juan Luis | |
dc.contributor.author | Herrero Gil, Carmen Rosario | |
dc.contributor.author | Bascunana, José | |
dc.contributor.author | Rubio-Rivas, Manuel | |
dc.contributor.author | Pintos Otero, Sara | |
dc.contributor.author | Martínez Sempere, Verónica | |
dc.contributor.author | Ballano Rodríguez-Solís, Jesús | |
dc.contributor.author | Gil Sánchez, Ricardo | |
dc.contributor.author | Luque del Pino, Jairo | |
dc.contributor.author | González Noya, Amara | |
dc.contributor.author | Navas-Alcántara, María Sierra | |
dc.contributor.author | Cortés Rodríguez, Begoña | |
dc.contributor.author | Alcalá, José Nicolás | |
dc.contributor.author | Suárez-Lombraña, Ana | |
dc.contributor.author | Soler, Jorge Andrés | |
dc.contributor.author | Gómez-Huelgas, Ricardo | |
dc.contributor.author | Casas-Rojo, José Manuel | |
dc.contributor.author | Millán Núñez-Cortés, Jesús | |
dc.contributor.author | SEMI‐COVID‐19 Network | |
dc.date.accessioned | 2021-06-17T07:03:47Z | |
dc.date.available | 2021-06-17T07:03:47Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://hdl.handle.net/10396/21422 | |
dc.description.abstract | Our main aim was to describe the effect on the severity of ACEI (angiotensin-converting enzyme inhibitor) and ARB (angiotensin II receptor blocker) during COVID-19 hospitalization. A retrospective, observational, multicenter study evaluating hospitalized patients with COVID-19 treated with ACEI/ARB. The primary endpoint was the incidence of the composite outcome of prognosis (IMV (invasive mechanical ventilation), NIMV (non-invasive mechanical ventilation), ICU admission (intensive care unit), and/or all-cause mortality). We evaluated both outcomes in patients whose treatment with ACEI/ARB was continued or withdrawn. Between February and June 2020, 11,205 patients were included, mean age 67 years (SD = 16.3) and 43.1% female; 2162 patients received ACEI/ARB treatment. ACEI/ARB treatment showed lower all-cause mortality (p < 0.0001). Hypertensive patients in the ACEI/ARB group had better results in IMV, ICU admission, and the composite outcome of prognosis (p < 0.0001 for all). No differences were found in the incidence of major adverse cardiovascular events. Patients previously treated with ACEI/ARB continuing treatment during hospitalization had a lower incidence of the composite outcome of prognosis than those whose treatment was withdrawn (RR 0.67, 95%CI 0.63–0.76). ARB was associated with better survival than ACEI (HR 0.77, 95%CI 0.62–0.96). ACEI/ARB treatment during COVID-19 hospitalization was associated with protection on mortality. The benefits were greater in hypertensive, those who continued treatment, and those taking ARB. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Journal of Clinical Medicine 10(12), 2642 (2021) | es_ES |
dc.subject | COVID‐19 | es_ES |
dc.subject | ACEI | es_ES |
dc.subject | ARB | es_ES |
dc.subject | Prognosis | es_ES |
dc.subject | MACE | es_ES |
dc.title | Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Withdrawal Is Associated with Higher Mortality in Hospitalized Patients with COVID-19 | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3390/jcm10122642 | es_ES |
dc.relation.projectID | Instituto de Salud Carlos III. CM19/00149 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |