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Functional Changes of T-Cell Subsets with Age and CMV Infection
dc.contributor.author | Hassouneh, Fakhri | |
dc.contributor.author | Goldeck, David | |
dc.contributor.author | Pera, Alejandra | |
dc.contributor.author | Heemst, Diana van | |
dc.contributor.author | Slagboom, P. Eline | |
dc.contributor.author | Pawelec, Graham | |
dc.contributor.author | Solana Lara, Rafael | |
dc.date.accessioned | 2021-10-01T10:17:36Z | |
dc.date.available | 2021-10-01T10:17:36Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://hdl.handle.net/10396/21761 | |
dc.description.abstract | Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is associated with the expansion of polyfunctional CD57+ T-cells in young and middle-aged individuals in response to different stimuli. Here, we expand our results on the effects of age and CMV infection on T-cell functionality in a cohort of healthy middle-aged and older individuals stratified by CMV serostatus. Specifically, we studied the polyfunctional responses (degranulation, IFN-γ and TNF-α production) of CD4+, CD8+, CD8+CD56+ (NKT-like), and CD4-CD8- (DN) T-cells according to CD57 expression in response to Staphylococcal Enterotoxin B (SEB). Our results show that CD57 expression by T-cells is not only a hallmark of CMV infection in young individuals but also at older ages. CD57+ T-cells are more polyfunctional than CD57− T-cells regardless of age. CMV-seronegative individuals have no or a very low percentages of cytotoxic CD4+ T-cells (CD1017a+) and CD4+CD57+ T-cells, supporting the notion that the expansion of these T-cells only occurs in the context of CMV infection. There was a functional shift in T-cells associated with CMV seropositivity, except in the NKT-like subset. Here, we show that the effect of CMV infection and age differ among T-cell subsets and that CMV is the major driving force for the expansion of highly polyfunctional CD57+ T-cells, emphasizing the necessity of considering CMV serology in any study of immunosenescence. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | International Journal of Molecular Sciences 22(18), 9973 (2021) | es_ES |
dc.subject | Aging | es_ES |
dc.subject | Cytomegalovirus | es_ES |
dc.subject | CD57 | es_ES |
dc.subject | T-cell response | es_ES |
dc.title | Functional Changes of T-Cell Subsets with Age and CMV Infection | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/ijms22189973 | es_ES |
dc.relation.projectID | Instituto de Salud Carlos III. PI16/01615 | es_ES |
dc.relation.projectID | Instituto de Salud Carlos III. PI19/00075 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/259679 (IDEAL) | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |