Listar Artículos, capítulos, libros...UCO por autor "2f69940f-c90b-49c7-a74f-af4d12a8d61f"
Mostrando ítems 1-16 de 16
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Alzheimer Identification through DNA Methylation and Artificial Intelligence Techniques
Alfonso Pérez, Gerardo; Caballero-Villarraso, Javier (MDPI, 2021)A nonlinear approach to identifying combinations of CpGs DNA methylation data, as biomarkers for Alzheimer (AD) disease, is presented in this paper. It will be shown that the presented algorithm can substantially reduce ... -
An Entropy Approach to Multiple Sclerosis Identification
Alfonso Pérez, Gerardo; Caballero-Villarraso, Javier (MDPI, 2022)Multiple sclerosis (MS) is a relatively common neurodegenerative illness that frequently causes a large level of disability in patients. While its cause is not fully understood, it is likely due to a combination of genetic ... -
CCR6 as a potential target for therapeutic antibodies for the treatment of inflammatory diseases
Gómez-Melero, Sara; Caballero-Villarraso, Javier (MDPI, 2023)The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling network is produced. This pathway is implicated ... -
Common Variants in 22 Genes Regulate Response to Metformin Intervention in Children with Obesity: A Pharmacogenetic Study of a Randomized Controlled Trial
Anguita-Ruiz, Augusto; Pastor-Villaescusa, Belén; Leis, Rosaura; Bueno, Gloria; Hoyos, Raúl; Vázquez-Cobela, Rocío; Latorre Millán, Miriam; Cañete Estrada, Ramón; Caballero-Villarraso, Javier; Gil, Ángel; Aguilera, Concepción M. (MDPI, 2019)Metformin is a first-line oral antidiabetic agent that has shown additional effects in treating obesity and metabolic syndrome. Inter-individual variability in metformin response could be partially explained by the genetic ... -
Comparative of transcranial magnetic stimulation and other treatments in experimental autoimmune encephalomyelitis
Medina Fernández, Francisco Javier; Escribano, Begoña M.; Luque, Evelio; Caballero-Villarraso, Javier; Gómez-Chaparro, José L.; Feijóo, Montserrat; García-Maceira, Fé I.; Pascual-Leone, Álvaro; Drucker Colín, René Raúl; Túnez, Isaac (Elsevier, 2018)The effects of transcranial magnetic stimulation (TMS), natalizumab (nata), dimethyl fumarate (DMF) and dexamethasone (DEX) on clinical score and oxidative stress produced by a single dose of myelin oligodendrocyte ... -
Comparative study between the diagnostic effectiveness of brain SPECT with [123I]Ioflupane and [123I]MIBG scintigraphy in multiple system atrophy
Villena-Salinas, Javier; Ortega-Lozano, Simeón José; Amrani-Raissouni, Tomader; Agüera Morales, Eduardo; Caballero-Villarraso, Javier (MDPI, 2024)Background: Multiple system atrophy (MSA) is a neurodegenerative disease. It has a fast progression, so early diagnosis is decisive. Two functional imaging tests can be involved in its diagnosis: [123I]Ioflupane SPECT and ... -
Development of a High-Throughput Calcium Mobilization Assay for CCR6 Receptor Coupled to Hydrolase Activity Readout
Gómez-Melero, Sara; García-Maceira, Fé I.; García-Maceira, Tania; Luna-Guerrero, Verónica; Montero-Peñalvo, Gracia; Caballero-Villarraso, Javier; Túnez, Isaac; Paz-Rojas, Elier (MDPI, 2022)CCR6 is a chemokine receptor highly implicated in inflammatory diseases and could be a potential therapeutic target; however, no therapeutic agents targeting CCR6 have progressed into clinical evaluation. Development of a ... -
Diagnostic effectiveness of [123I] Ioflupane single photon emission computed tomography (SPECT) in multiple system atrophy
Villena-Salinas, Javier; Ortega-Lozano, Simeón José; Amrani-Raissouni, Tomader; Agüera Morales, Eduardo; Caballero-Villarraso, Javier (MDPI, 2023)Background: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder that has no curative treatment. Diagnosis is based on a set of criteria established by Gilman (1998 and 2008) and recently updated ... -
Effect of the combination of different therapies on oxidative stress in the experimental model of multiple sclerosis
Escribano, Begoña M.; Muñoz Jurado, Ana; Luque, Evelio; Galván, Alberto; Latorre, Manuel; Caballero-Villarraso, Javier; Giraldo, Ana I.; Agüera, Eduardo; Túnez, Isaac (IBRO, 2023)Oxidative stress is heavily involved in several pathological features of Multiple Sclerosis (MS), such as myelin destruction, axonal degeneration, and inflammation. Different therapies have been shown to reduce the oxidative ... -
Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
Martín-Piedra, Laura; Alcalá Díaz, Juan Francisco; Gutiérrez Mariscal, Francisco Miguel; Arenas de Larriva, Antonio P.; Romero-Cabrera, Juan Luis; Torres‑Peña, J.D.; Caballero-Villarraso, Javier; Luque, Raúl M.; Pérez-Martínez, Pablo; López-Miranda, José; Delgado-Lista, Javier (MDPI, 2021)Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing ... -
Extra-Virgin Olive Oil Modifies the Changes Induced in Non-Nervous Organs and Tissues by Experimental Autoimmune Encephalomyelitis Models
Conde, Cristina; Escribano, Begoña M.; Luque, Evelio; Feijóo, Montserrat; Caballero-Villarraso, Javier; Valdelvira, Manuel E.; Ochoa Sepúlveda, Juan J.; Lillo, Rafael; Paz, Elier; Santamaría, Abel; Agüera, Eduardo; Túnez, Isaac (MDPI, 2019)This study reveals the existence of oxidative stress (reactive oxygen species (ROS)) in non-nervous organs and tissues in multiple sclerosis (MS) by means of a model of experimental autoimmune encephalomyelitis (EAE) in ... -
Follow-up findings in multiple system atrophy from [123I]Ioflupane Single-Photon Emission Computed Tomography (SPECT): a prospective study
Villena-Salinas, Javier; Ortega-Lozano, Simeón José; Amrani-Raissouni, Tomader; Agüera, Eduardo; Caballero-Villarraso, Javier (MDPI, 2023)Background: Multiple system atrophy (MSA) is subdivided into two types: MSA-P (parkinsonian) and MSA-C (cerebellar). Brain SPECT allows for the detection of nigrostriatal involvement, even in the early stages. To date, the ... -
Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients—A Comprehensive Review
Gómez-Melero, Sara; Caballero-Villarraso, Javier; Escribano, Begoña M.; Galvao-Carmona, Alejandro; Túnez, Isaac; Agüera Morales, Eduardo (MDPI, 2024)Multiple sclerosis (MS) is characterized by a variety of symptoms that have a major impact on quality of life (QoL) even in early stages. In addition to individual motor, sensory, visual disturbances, and brainstem and ... -
Neural Network Aided Detection of Huntington Disease
Alfonso Pérez, Gerardo; Caballero-Villarraso, Javier (MDPI, 2022)Huntington Disease (HD) is a degenerative neurological disease that causes a significant impact on the quality of life of the patient and eventually death. In this paper we present an approach to create a biomarker using ... -
Neuroprotective effect of S-allyl cysteine on an experimental model of multiple sclerosis: Antioxidant effects
Escribano, Begoña M.; Agüera Carmona, Eduardo; Aguilar-Luque, Macarena; Luque, Evelio; Feijóo, Montserrat; Latorre, Manuel; Giraldo, Ana I.; Galván-Jurado, A.; Caballero-Villarraso, Javier; García-Maceira, Fé I.; Santamaría, Abel; Túnez, Isaac (Elsevier, 2018)S-allyl cysteine (SAC), has shown itself to performance important activity as a neuroprotective agent. This action is prompted by antioxidative activity. The aim of this study was to evaluate the neuroprotective effect of ... -
Prevalence of active primitive reflexes and craniosacral blocks in apparently healthy children and relationships with neurodevelopment disturbances
León-Bravo, Gema; Cantarero, Irene; Caballero-Villarraso, Javier (MDPI, 2023)Background: In healthy children, the frequency of the anomalous persistence of primitive reflexes (PRs) and craniosacral blocks (CBs) is unknown, as well as their impact on neurodevelopment, behaviour disorders and related ...