Listar Artículos, capítulos, libros...UCO por autor "5555dd0e-560b-4e17-a5ab-a41864b9d964"
Mostrando ítems 41-60 de 60
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Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users
Luciano-Mateo, Fedra; Hernández-Aguilera, Anna; Cabré, Noemí; Camps, Jordi; Fernández-Arroyo, Salvador; López-Miranda, José; Menéndez, Javier A.; Joven, Jorge (MDPI, 2017)Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive ... -
NUTRITECH
López-Miranda, José (Oficina de Transferencia de Resultados de la Investigación, 2013)NutriTech is a European Commission funded FP7 research project (2012-2015) The goal of NutriTech is to quantify the effect of diet on “phenotypic flexibility”. Phenotypic flexibility extends on metabolic flexibility (the ... -
Owning a Pet Is Associated with Changes in the Composition of Gut Microbiota and Could Influence the Risk of Metabolic Disorders in Humans
Arenas-Montes, Javier; Pérez-Martínez, Pablo; Vals-Delgado, Cristina; Romero-Cabrera, Juan Luis; Cardelo, Magdalena P.; León Acuña, Ana; Quintana-Navarro, Gracia M.; Alcalá Díaz, Juan Francisco; López-Miranda, José; Camargo García, A.; Pérez-Jiménez, Francisco (MDPI, 2021)Pet ownership positively influences clinical outcomes in cardiovascular prevention. Additionally, cardiovascular disease (CVD) has been previously linked to microbiota dysbiosis. We evaluated the influence of owning a pet ... -
Phenolic Content of Virgin Olive Oil Improves Ischemic Reactive Hyperemia in Hypercholesterolemic Patients
Ruano, Juan; López Miranda, José; Fuentes, Francisco; Moreno, Juan Antonio; Bellido, Cecilia; Pérez-Martínez, Pablo; Lozano, Aquiles; Gómez, Purificación; Jiménez, Yolanda; Pérez-Jiménez, Francisco (Elsevier, 2005)The goal of this study was to evaluate the effects of the phenolic content of virgin olive oil on endothelial reactivity. Background Endothelial-dependent vasodilatation is impaired during the postprandial state, and ... -
Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
Boughanem, Hatim; Yubero-Serrano, Elena M.; López-Miranda, José; Tinahones, Francisco J.; Macías-González, Manuel (MDPI, 2021)Evidence from observational and in vitro studies suggests that insulin growth-factor-binding protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as obesity, insulin resistance, metabolic ... -
Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids
Rangel Zúñiga, Oriol Alberto; Camargo García, A.; Marín, Carmen; Peña Orihuela, Judhit; Pérez-Martínez, Pablo; Delgado-Lista, Javier; González Guardia, Lorena; Yubero-Serrano, Elena M.; Tinahones, Francisco J.; Malagón, María M.; Pérez-Jiménez, Francisco; Roche, Helen M.; López-Miranda, José (BioMed Central, 2015)Background: Metabolic syndrome is a multi-component disorder associated to a high risk of cardiovascular disease. Its etiology is the result of a complex interaction between genetic and environmental factors, including ... -
Quality and Quantity of Protein Intake Influence Incidence of Type 2 Diabetes Mellitus in Coronary Heart Disease Patients: From the CORDIOPREV Study
Cruz‐Ares, Silvia de la; Gutiérrez Mariscal, Francisco Miguel; Alcalá Díaz, Juan Francisco; Quintana-Navarro, Gracia M.; Podadera-Herreros, Alicia; Cardelo, Magdalena P.; Torres‑Peña, J.D.; Arenas de Larriva, Antonio P.; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; López-Miranda, José (MDPI, 2021)Evidence suggests that enriching a diet with plant-based proteins could reduce the risk of developing type 2 diabetes mellitus. In the present work, we evaluated the association between the change in plant protein intake ... -
Rab18 Dynamics in Adipocytes in Relation to Lipogenesis, Lipolysis and Obesity
Pulido, Marina R.; Díaz-Ruiz, Alberto; Jiménez-Gómez, Yolanda; García-Navarro, Socorro; Gracia-Navarro, F.; Frühbeck, Gema; Vázquez Martínez, Rafael; Tinahones, Francisco J.; Malagón, María M.; López-Miranda, José (Public Libray of Science (PLOS), 2011)Lipid droplets (LDs) are organelles that coordinate lipid storage and mobilization, both processes being especially important in cells specialized in managing fat, the adipocytes. Proteomic analyses of LDs have consistently ... -
Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity
Pulido, Marina R.; Díaz-Ruiz, Alberto; Jiménez-Gómez, Yolanda; García Navarro, S.; Gracia-Navarro, F.; Tinahones, Francisco J.; López-Miranda, José; Frühbeck, Gema; Vázquez Martínez, Rafael; Malagón, María M. (PLOS, 2011)Lipid droplets (LDs) are organelles that coordinate lipid storage and mobilization, both processes being especially important in cells specialized in managing fat, the adipocytes. Proteomic analyses of LDs have consistently ... -
Telomere maintenance is associated with type 2 diabetes remission in response to a long-term dietary intervention without non-weight loss in patients with coronary heart disease: from the CORDIOPREV randomized controlled trial
Ojeda-Rodríguez, Ana; Alcalá Díaz, Juan Francisco; Rangel Zúñiga, Oriol Alberto; Arenas de Larriva, Antonio P.; Gutiérrez Mariscal, Francisco Miguel; Torres‑Peña, J.D.; Mora-Ortiz, Marina; Romero-Cabrera, Juan Luis; Luque, Raúl M.; Ordovas, José M.; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; López-Miranda, José (MDPI, 2024)In order to evaluate whether telomere maintenance is associated with type 2 diabetes remission, newly diagnosed type 2 diabetes patients without glucose-lowering treatment (183 out of 1002) from the CORDIOPREV study ... -
The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population
Pérez Martínez, Pablo; Pérez Jiménez, Francisco; Ordovás, José María; Bellido, Cecilia; Moreno, Juan; Gómez, Purificación; Marín, Carmen; Fernández de la Puebla, Rafael Ángel; Paniagua, Juan Antonio; López Miranda, José (Elsevier, 2007)Our goal was to determine whether the presence of the −516C/T polymorphism in the APOB gene promoter modifies the lipid response to changes in the amount and quality of dietary fat. We studied 97 young healthy volunteers ... -
The Apolipoprotein E Gene Promoter (−219G/T) Polymorphism Determines Insulin Sensitivity in Response to Dietary Fat in Healthy Young Adults
Moreno, Juan Antonio; Pérez-Jiménez, Francisco; Marín, Carmen; Pérez-Martínez, Pablo; Moreno, Rafael; Gómez, Purificación; Jiménez Gómez, Yolanda; Paniagua, Juan Antonio; Lairon, Denis; López Miranda, José (Elsevier, 2005)Insulin sensitivity (IS) is determined by genetic and environmental factors, including diet. The apoE gene promoter −219G/T polymorphism is associated with coronary heart disease and increased postprandial triacylglycerol-rich ... -
The chronic intake of a Mediterranean diet enriched in virgin olive oil, decreases nuclear transcription factor kappaB activation in peripheral blood mononuclear cells from healthy men
Pérez Martínez, Pablo; López Miranda, José; Blanco-Colio, Luis M.; Bellido, Cecilia; Jiménez, Yolanda; Moreno, Juan; Delgado-Lista, Javier; Egido, J.; Pérez Jiménez, Francisco (Elsevier, 2007)Objetive Nuclear transcription factor κB (NF-κB) plays a key role in the inflammatory response and can be modulate by dietary fat. We have examined the effect of three diets, with different fat composition, on the activation ... -
The Effect of Dietary Fat on LDL Size Is Influenced by Apolipoprotein E Genotype in Healthy Subjects
Moreno, Juan Antonio; Pérez-Jiménez, Francisco; Marín, Carmen; Gómez, Purificación; Pérez-Martínez, Pablo; Moreno, Rafael; Bellido, Cecilia; Fuentes, Francisco; López Miranda, José (American Society for Nutrition, 2004)LDL particle size is dependent on both genetic factors and environmental factors such as dietary fat composition. The apolipoprotein E (apoE) genotype is a major genetic determinant of LDL size. Thus, the aim of this work ... -
The Fluid Aspect of the Mediterranean Diet in the Prevention and Management of Cardiovascular Disease and Diabetes: The Role of Polyphenol Content in Moderate Consumption of Wine and Olive Oil
Ditano-Vázquez, Paola; Torres‑Peña, J.D.; Galeano-Valle, Francisco; Pérez-Caballero, Ana I.; Demelo-Rodríguez, Pablo; López-Miranda, José; Katsiki, Niki; Delgado-Lista, Javier; Álvarez-Sala-Walther, Luis A. (MDPI, 2019)A growing interest has emerged in the beneficial effects of plant-based diets for the prevention of cardiovascular disease, diabetes and obesity. The Mediterranean diet, one of the most widely evaluated dietary patterns ... -
The influence of the apolipoprotein E gene promoter (-219G/T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males
Moreno, Juan Antonio; López Miranda, José; Marín, Carmen; Paniagua, Juan Antonio; Ordovas, José M.; Pérez-Jiménez, Francisco (ASBMB, 2003)The apolipoprotein E (apoE) gene promoter (−219G/T) polymorphism has been associated with increased risk of myocardial infarction, premature coronary heart disease, and decreased plasma apoE concentrations. We examined ... -
The stromal-vascular fraction of adipose tissue contributes to major differences between subcutaneous and visceral fat depots
Peinado, Juan R.; Jiménez Gómez, Yolanda; Pulido, Marina R.; Ortega-Bellido, María; Díaz-López, César; Padillo, Francisco; López Miranda, José; Vazquez-Martínez, Rafael; Malagón, María M. (Wiley, 2010)Adipose tissue represents a complex tissue both in terms of its cellular composition, as it includes mature adipocytes and the various cell types comprising the stromal-vascular fraction (SVF), and in relation to the ... -
Transcriptomic Coordination in the Human Metabolic Network Reveals Links between n-3 Fat Intake, Adipose Tissue Gene Expression and Metabolic Health
Morine, Melissa J.; Tierney, Audrey C.; Van Ommen, Ben; Daniel, Hannelore; Toomey, Sinead; Gjelstad, Ingrid M.F.; Gormley, Isobel C.; Drevon, Christian A.; Pérez-Martínez, Pablo; Roche, Helen M.; López-Miranda, José (Public Library Of Science (PLOS), 2011)Understanding the molecular link between diet and health is a key goal in nutritional systems biology. As an alternative to pathway analysis, we have developed a joint multivariate and network-based approach to analysis ... -
Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy caucasian population
Moreno-Luna, Rafael; Pérez Jiménez, Francisco; Marín, Carmen; Pérez Martínez, Pablo; Gómez, Purificación; Jiménez Gómez, Yolanda; Delgado-Lista, Javier; Moreno, Juan; Tanaka, Toshiko; Ordovás, José María; López Miranda, José (Endocrine Society, 2007)Background: Apolipoprotein A5 (APOA5) plays an important role in plasma triacylglycerol (TG) homeostasis. Five polymorphisms (1131T>C, c.-3A>G, c.56C>G, IVS3+476G>A, and c.1259T>C) in the APOA5 gene define three common ... -
Vitamin D Endocrine System and COVID-19. Treatment with Calcifediol
Quesada Gómez, José Manuel; López-Miranda, José; Entrenas-Castillo, Marta; Casado-Díaz, Antonio; Nogues y Solans, Xavier; Mansur, José Luis; Bouillon, Roger (MDPI, 2022)The COVID-19 pandemic is the greatest challenge facing modern medicine and public health systems. The viral evolution of SARS-CoV-2, with the emergence of new variants with in-creased infectious potential, is a cause for ...