Listar DMed-Artículos, capítulos... por autor "49850cb1-0089-44a8-a1fb-60684e4fd5ad"

Mostrando ítems 1-8 de 8

    • Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure 

      López-Baltanás, Rodrigo; Rodríguez-Ortiz, Maria E.; Díaz Tocados, Juan Manuel; Martínez-Moreno, Julio M.; Membrives, Cristina; Rodelo Haad, Cristian Roberto; Pendón-Ruiz de Mier, María V.; Pendón-Ruiz de Mier, María V.; Rodríguez, Mariano; Canalejo, Antonio; Almadén Peña, Yolanda; Muñoz-Castañeda, Juan R. (MDPI, 2023)
      whether a dietary Mg supplementation might attenuate vascular dysfunction through the modulation of oxidative stress and inflammation in concurrent MetS and CKD. Methods: A rat model of MetS (Zucker strain) with CKD (5/6 ...

    • In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation 

      Martínez-Moreno, Julio M.; Muñoz-Castañeda, Juan R.; Herencia, Carmen; Montes de Oca, Addy; Estepa Nieto, José Carlos; Canalejo, Rocío; Rodríguez-Ortiz, Maria E.; Aguilera Tejero, Escolástico; Canalejo, Antonio; Rodríguez, Mariano; Almadén Peña, Yolanda; Pérez-Martínez, Pablo (American Journal of Physiology, 2012)
      The present study investigates the differential effect of two vitamin D receptor agonists, calcitriol and paricalcitol, on human aortic smooth muscle cells calcification in vitro. Human vascular smooth muscle cells were ...

    • Klotho/FGF23 and Wnt Signaling as Important Players in the Comorbidities Associated with Chronic Kidney Disease 

      Muñoz-Castañeda, Juan R.; Rodelo Haad, Cristian Roberto; Pendón-Ruiz de Mier, María V.; Martín-Malo, Alejandro; Santamaría, Rafael; Rodríguez, Mariano (MDPI, 2020)
      Fibroblast Growth Factor 23 (FGF23) and Klotho play an essential role in the regulation of mineral metabolism, and both are altered as a consequence of renal failure. FGF23 increases to augment phosphaturia, which prevents ...

    • Magnesium Inhibits Wnt/β-Catenin Activity and Reverses the Osteogenic Transformation of Vascular Smooth Muscle Cells 

      Montes de Oca, Addy; Guerrero Pavón, Fátima; Martínez-Moreno, Julio M.; Madueño, Juan A.; Herencia, Carmen; Peralta, Alan; Almadén Peña, Yolanda; López, Ignacio; Aguilera Tejero, Escolástico; Gundlach, Kristina; Büchel, Janine; Peter, Mirjam E.; Passlick-Deetjen, Jutta; Rodríguez Portillo, Mariano; Muñoz-Castañeda, Juan R. (Public Library of Science, 2014)
      Magnesium reduces vascular smooth muscle cell (VSMC) calcification in vitro but the mechanism has not been revealed so far. This work used only slightly increased magnesium levels and aimed at determining: a) whether ...

    • Magnesium Replacement to Protect Cardiovascular and Kidney Damage? Lack of Prospective Clinical Trials 

      Muñoz-Castañeda, Juan R.; Pendón-Ruiz de Mier, María V.; Rodríguez, Mariano; Rodríguez-Ortiz, Maria E. (MDPI, 2018)
      Patients with advanced chronic kidney disease exhibit an increase in cardiovascular mortality. Recent works have shown that low levels of magnesium are associated with increased cardiovascular and all-cause mortality in ...

    • Nuclear Translocation of b-Catenin during Mesenchymal Stem Cells Differentiation into Hepatocytes Is Associated with a Tumoral Phenotype 

      Herencia, Carmen; Martínez-Moreno, Julio M.; Herrera, Concepción; Corrales, Fernando J.; Santiago-Mora, Raquel; Espejo, Isabel; Barcos, Montserrat; Almadén Peña, Yolanda; Mata, Manuel de la; Rodríguez-Ariza, Antonio; Muñoz-Castañeda, Juan R. (Public Libray of Science (PLOS), 2012)
      Wnt/b-catenin pathway controls biochemical processes related to cell differentiation. In committed cells the alteration of this pathway has been associated with tumors as hepatocellular carcinoma or hepatoblastoma. The ...

    • TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways 

      Guerrero Pavón, Fátima; Herencia, Carmen; Almadén Peña, Yolanda; Martínez-Moreno, Julio M.; Montes de Oca, Addy; Rodríguez-Ortiz, Maria E.; Díaz Tocados, Juan Manuel; Florio, Mónica; López, Ignacio; Richards, William G.; Rodríguez Portillo, Mariano; Aguilera Tejero, Escolástico; Muñoz-Castañeda, Juan R. (Public Library of Science, 2014)
      Background: Transforming growth factor-b (TGF-b) is a key cytokine during differentiation of mesenchymal stem cells (MSC) into vascular smooth muscle cells (VSMC). High phosphate induces a phenotypic transformation of ...

    • Uremic toxins induce THP-1 Monocyte endothelial adhesion and migration through specific miRNA expression 

      Carmona, Andrés; Guerrero, Fátima; Muñoz-Castañeda, Juan R.; Jiménez, María José; Rodríguez, M.; Soriano, Sagrario; Martín-Malo, Alejandro (MDPI, 2023)
      Atherosclerosis is initiated by the activation of endothelial cells that allows monocyte adhesion and transmigration through the vascular wall. The accumulation of uremic toxins such as indoxyl sulphate (IS) and p-cresol ...