• Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations 

      Pérez-Caballero, Ana I.; García-Ríos, Antonio; Gómez-Luna, María J.; Gómez-Luna, Purificación; Dembinska-Kiec, Aldona; Rodríguez-Cantalejo, Fernando; Camargo García, A.; Marín, Carmen; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; Tinahones, Francisco J.; Pérez-Jiménez, Francisco; Roche, Helen M.; López-Miranda, José (Public Library Of Science (PLOS), 2012)
      Background: TCF7L2 rs7903146 is an important genetic factor predicting type 2 diabetes (T2DM) which has also been linked to higher cardiovascular risk. To date, there is little information about the additional impact of ...
    • Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome 

      García-Ríos, Antonio; Mc Monagle, Jolene; Gulseth, Hanne L.; Ordovás, José María; Shaw, Danielle I.; Karlström, Brita; Kiec-Wilk, Beata; Blaak, Ellen E.; Helal, Olfa; Malczewska-Malec, Malgorzata; Defoort, Catherine; Risérus, Ulf; Saris, Wim H.M.; Lovegrove, Julie A.; Drevon, Christian A.; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Roche, Helen M.; López-Miranda, José (Public Library Of Science (PLOS), 2011)
      Glucokinase Regulatory Protein (GCKR) plays a central role regulating both hepatic triglyceride and glucose metabolism. Fatty acids are key metabolic regulators, which interact with genetic factors and influence glucose ...
    • Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids 

      Rangel Zúñiga, Oriol Alberto; Camargo García, A.; Marín, Carmen; Peña Orihuela, Judhit; Pérez-Martínez, Pablo; Delgado-Lista, Javier; González Guardia, Lorena; Yubero-Serrano, Elena M.; Tinahones, Francisco J.; Malagón, María M.; Pérez-Jiménez, Francisco; Roche, Helen M.; López-Miranda, José (BioMed Central, 2015)
      Background: Metabolic syndrome is a multi-component disorder associated to a high risk of cardiovascular disease. Its etiology is the result of a complex interaction between genetic and environmental factors, including ...
    • Transcriptomic Coordination in the Human Metabolic Network Reveals Links between n-3 Fat Intake, Adipose Tissue Gene Expression and Metabolic Health 

      Morine, Melissa J.; Tierney, Audrey C.; Van Ommen, Ben; Daniel, Hannelore; Toomey, Sinead; Gjelstad, Ingrid M.F.; Gormley, Isobel C.; Drevon, Christian A.; Pérez-Martínez, Pablo; Roche, Helen M.; López-Miranda, José (Public Library Of Science (PLOS), 2011)
      Understanding the molecular link between diet and health is a key goal in nutritional systems biology. As an alternative to pathway analysis, we have developed a joint multivariate and network-based approach to analysis ...