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Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure
dc.contributor.author | López-Baltanás, Rodrigo | |
dc.contributor.author | Rodríguez-Ortiz, Maria E. | |
dc.contributor.author | Díaz Tocados, Juan Manuel | |
dc.contributor.author | Martínez-Moreno, Julio M. | |
dc.contributor.author | Membrives, Cristina | |
dc.contributor.author | Rodelo Haad, Cristian Roberto | |
dc.contributor.author | Pendón-Ruiz de Mier, María V. | |
dc.contributor.author | Pendón-Ruiz de Mier, María V. | |
dc.contributor.author | Rodríguez, Mariano | |
dc.contributor.author | Canalejo, Antonio | |
dc.contributor.author | Almadén Peña, Yolanda | |
dc.contributor.author | Muñoz-Castañeda, Juan R. | |
dc.date.accessioned | 2023-01-31T13:44:57Z | |
dc.date.available | 2023-01-31T13:44:57Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | http://hdl.handle.net/10396/24590 | |
dc.description.abstract | whether a dietary Mg supplementation might attenuate vascular dysfunction through the modulation of oxidative stress and inflammation in concurrent MetS and CKD. Methods: A rat model of MetS (Zucker strain) with CKD (5/6 nephrectomy, Nx) was used. Nephrectomized animals were fed a normal 0.1%Mg (MetS+Nx+Mg0.1%) or a supplemented 0.6%Mg (MetS+Nx+Mg0.6%) diet; Sham-operated rats with MetS receiving 0.1%Mg were used as controls. Results: As compared to controls, the MetS+Nx-Mg0.1% group showed a significant increase in oxidative stress and inflammation biomarkers (lipid peroxidation and aortic interleukin-1b and -6 expression) and Endothelin-1 levels, a decrease in nitric oxide and a worsening in uremia and MetS associated pathology as hypertension, and abnormal glucose and lipid profile. Moreover, proteomic evaluation revealed changes mainly related to lipid metabolism and CVD markers. By contrast, in the MetS+Nx+Mg0.6% group, these parameters remained largely similar to controls. Conclusion: In concurrent MetS and CKD, dietary Mg supplementation reduced inflammation and oxidative stress and improved vascular function. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Antioxidants, 12(2), 283; (2023) | es_ES |
dc.subject | Magnesium | es_ES |
dc.subject | Metabolic syndrome | es_ES |
dc.subject | Chronic kidney disease | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | Oxidative stress | es_ES |
dc.subject | Vascular dysfunction | es_ES |
dc.title | Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/antiox12020283 | es_ES |
dc.relation.projectID | Gobierno de España. PI20/0660 (FEDER) | es_ES |
dc.relation.projectID | Gobierno de España. PI21/00654 (FEDER) | es_ES |
dc.relation.projectID | Junta de Andalucía. PI-0071-202 | es_ES |
dc.relation.projectID | Junta de Andalucía. Y20_00773 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |