Mostrar el registro sencillo del ítem
Helicobacter Species and Hepato-Biliary Tract Malignancies: A Systematic Review and Meta-Analysis
dc.contributor.author | Gros, Beatriz | |
dc.contributor.author | Gómez Pérez, Alberto | |
dc.contributor.author | Pleguezuelo, María | |
dc.contributor.author | Serrano Ruiz, Francisco Javier | |
dc.contributor.author | Serrano Ruiz, Francisco Javier | |
dc.contributor.author | de la Mata, Manuel | |
dc.contributor.author | Rodríguez-Perálvarez, Manuel | |
dc.date.accessioned | 2023-02-02T12:01:58Z | |
dc.date.available | 2023-02-02T12:01:58Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | http://hdl.handle.net/10396/24609 | |
dc.description.abstract | Helicobacter species may cause chronic inflammation of the biliary tract, but its relationship with cancer is controversial. We performed a systematic review and meta-analysis to evaluate the association between Helicobacter species and hepatobiliary tract malignancies. Twenty-six studies (4083 patients) were included in qualitative synthesis, and 18 studies (n = 1895 qualified for meta-analysis. All studies were at high-intermediate risk of bias. Most studies combined several direct microbiological methods, mostly PCR (23 studies), culture (8 studies), and/or CLOtest (5 studies). Different specimens alone or in combination were investigated, most frequently bile (16 studies), serum (7 studies), liver/biliary tissue (8 studies), and gastric tissue (3 studies). Patients with Helicobacter species infection had an increased risk of hepatobiliary tract malignancies (OR = 3.61 [95% CI 2.18–6.00]; p < 0.0001), with high heterogeneity in the analysis (I2 = 61%; p = 0.0003). This effect was consistent when Helicobacter was assessed in bile (OR = 3.57 [95% CI 1.73–7.39]; p = 0.0006), gastric tissue (OR = 42.63 [95% CI 5.25–346.24]; p = 0.0004), liver/biliary tissue (OR = 4.92 [95% CI 1.90–12.76]; p = 0.001) and serum (OR = 1.38 [95% CI 1.00–1.90]; p = 0.05). Heterogeneity was reduced in these sub-analyses (I2 = 0–27%; p = ns), except for liver/biliary tissue (I2 = 57%; p = 0.02). In conclusion, based on low-certainty data, Helicobacter species chronic infection is associated with a tripled risk of hepatobiliary tract malignancy. Prospective studies are required to delineate public health interventions. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Cancers, 15(3), 595 (2023) | es_ES |
dc.subject | Helicobacter | es_ES |
dc.subject | Cholangiocarcinoma | es_ES |
dc.subject | Cancer | es_ES |
dc.subject | Neoplasms | es_ES |
dc.title | Helicobacter Species and Hepato-Biliary Tract Malignancies: A Systematic Review and Meta-Analysis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/cancers15030595 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |