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dc.contributor.authorPulido-Escribano, Victoria
dc.contributor.authorTorrecillas‐Baena, Bárbara
dc.contributor.authorDorado, Gabriel
dc.contributor.authorGálvez-Moreno, María Ángeles
dc.contributor.authorCamacho-Cardenosa, Marta
dc.contributor.authorCasado-Díaz, Antonio
dc.contributor.authorPulido-Escribano, Victoria
dc.contributor.authorTorrecillas‐Baena, Bárbara
dc.contributor.authorDorado, Gabriel
dc.contributor.authorGálvez-Moreno, M. Ángeles
dc.contributor.authorCamacho-Cardenosa, Marta
dc.contributor.authorCasado-Díaz, Antonio
dc.date.accessioned2023-02-22T12:27:17Z
dc.date.available2023-02-22T12:27:17Z
dc.date.issued2023
dc.identifier.urihttp://hdl.handle.net/10396/24766
dc.description.abstractHard-to-heal chronic wounds associated with aging and high-prevalence pathologies, such as diabetes, are a global health problem. Therefore, it is necessary to advance effective treatments to accelerate wound healing. Among these potential treatments are new therapies based on mesenchymal stem cells (MSC) and their secretomes, including extracellular vesicles (EV). They have an important therapeutic potential for the treatment of chronic ulcers, due to their immunomodulatory activity, as well as their ability to induce angiogenesis, cell proliferation and cell migration. The use of MSC-derived EV in regenerative medicine involves cell-free therapies that decrease risks associated with cell therapies, such as the potential development of tumors. However, the short half-life of MSC-EV is a limitation for their clinical use. A therapeutic strategy to increase the regenerative efficiency of EV in wounds is to encapsulate them in biomaterials. The latter must protect and progressively release EV in damaged tissues, optimizing healing. Biomaterials that can be used include hydrogels. These, in addition to acting as a vehicle for sustained application of EV, can create favorable environments for wound healing. Thus, the aim of this review is to critically describe the latest advances in the development of such therapeutic strategies. It highlights the significance and clinical potential of these new therapies, as well as the need to develop clinical trials, to ascertain their performance.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceApplied Science, 13(4), 2702 (2023)es_ES
dc.subjectMesenchymal stem cellses_ES
dc.subjectExtracellular vesicleses_ES
dc.subjectWound healinges_ES
dc.subjectSkines_ES
dc.subjectWound dressingses_ES
dc.subjectBiomaterialses_ES
dc.subjectHydrogelses_ES
dc.subjectDiabeteses_ES
dc.titleCombination of Biomaterials and Extracellular Vesicles from Mesenchymal Stem-Cells: New Therapeutic Strategies for Skin-Wound Healinges_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/app13042702es_ES
dc.relation.projectIDGobierno de España. PI18/0165es_ES
dc.relation.projectIDGobierno de España. PI21/01935es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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