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dc.contributor.authorBallesteros-Gómez, A.
dc.contributor.authorVan den Eede, Nele
dc.contributor.authorCovaci, A.
dc.date.accessioned2024-01-31T17:28:22Z
dc.date.available2024-01-31T17:28:22Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10396/26909
dc.description.abstractResorcinol bis(diphenylphosphate) (RDP) is widely used as a flame retardant in electrical/electronic products and constitutes a suitable alternative to decabrominated diphenyl ether. Due to its toxicity and its recently reported ubiquity in electronics and house dust, there are increasing concerns about human exposure to this emerging contaminant. With the aim of identifying human-specific biomarkers, the in vitro metabolism of RDP and its oligomers was investigated using human liver microsomes and human liver cytosol. Mono- and dihydroxy-metabolites, together with glucuronidated and sulfated metabolites, were detected. Regarding RDP oligomers, only a hydroxy-metabolite of the dimer could be detected. RDP and its oligomers were also readily hydrolyzed, giving rise to a variety of compounds, such as diphenyl phosphate, para-hydroxy-triphenyl phosphate, and para-hydroxy RDP, which were further metabolized. These degradation products or impurities are possibly of environmental importance in future studies.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherACSes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceBallesteros‐Gómez, A., Van Den Eede, N., & Covaci, A. (2015). In vitro human metabolism of the flame retardant resorcinol bis(diphenylphosphate) (RDP). Environmental Science & Technology, 49(6), 3897-3904. https://doi.org/10.1021/es505857ees_ES
dc.subjectResorcinol bis-(diphenylphosphate)es_ES
dc.subjectHuman liver microsomeses_ES
dc.subjectMetabolismes_ES
dc.subjectIn vitroes_ES
dc.subjectMass spectrometryes_ES
dc.titleIn Vitro Human Metabolism of the Flame Retardant Resorcinol Bis(diphenylphosphate) (RDP)es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1021/es505857ees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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