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Efficacy of a multivalent vaccine against Fasciola hepatica infection in sheep
dc.contributor.author | Zafra Leva, Rafael | |
dc.contributor.author | Buffoni Perazzo, Leandro | |
dc.contributor.author | Pérez Caballero, Raúl | |
dc.contributor.author | Molina-Hernández, Verónica | |
dc.contributor.author | Ruiz-Campillo, María Teresa | |
dc.contributor.author | Pérez, José | |
dc.contributor.author | Martínez Moreno, Álvaro | |
dc.contributor.author | Martínez-Moreno, Francisco Javier | |
dc.date.accessioned | 2024-02-06T09:59:06Z | |
dc.date.available | 2024-02-06T09:59:06Z | |
dc.date.issued | 2021 | |
dc.identifier.isbn | 0928-4249 | |
dc.identifier.uri | http://hdl.handle.net/10396/27151 | |
dc.description.abstract | In this work we report the protection found in a vaccination trial performed in sheep with two different vaccines composed each one by a cocktail of antigens (rCL1, rPrx, rHDM and rLAP) formulated in two different adjuvants (Montanide ISA 61 VG (G1) and Alhydrogel®(G2)). The parameters of protection tested were fluke burden, faecal egg count and evaluation of hepatic lesions. In vaccinated group 1 we found a significant decrease in fluke burden in comparison to both unimmunised and infected control group (37.2%; p = 0.002) and to vaccinated group 2 (Alhydrogel®) (27.08%; p = 0.016). The lower fluke burden found in G1 was accompanied by a decrease in egg output of 28.71% in comparison with the infected control group. Additionally, gross hepatic lesions found in vaccine 1 group showed a significant decrease (p = 0.03) in comparison with unimmunised-infected group. The serological study showed the highest level for both IgG1 and IgG2 in animals from group 1. All these data support the hypothesis of protection found in vaccine 1 group. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Zafra, R., Buffoni, L., Pérez–Caballero, R., Molina-Hernández, V., Ruiz-Campillo, M. T., Pérez, J., Martínez-Moreno, Á., & Moreno, F. J. M. (2021). Efficacy of a multivalent vaccine against fasciola hepatica infection in sheep. Veterinary Research, 52(1). https://doi.org/10.1186/s13567-021-00895-0 | es_ES |
dc.subject | Fasciola hepatica | es_ES |
dc.subject | Vaccine | es_ES |
dc.subject | Sheep | es_ES |
dc.subject | Protection | es_ES |
dc.title | Efficacy of a multivalent vaccine against Fasciola hepatica infection in sheep | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.1186/s13567-021-00895-0 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/635408 (PARAGONE) | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |