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Denervated muscle extract promotes recovery of muscle atrophy through activation of satellite cells. An experimental study

dc.contributor.authorAgüera, Eduardo
dc.contributor.authorCastilla, Salvador
dc.contributor.authorLuque, Evelio
dc.contributor.authorJimena Medina, Ignacio
dc.contributor.authorRuz‐Caracuel, Ignacio
dc.contributor.authorLeiva-Cepas, Fernando
dc.contributor.authorPeña, José
dc.date.accessioned2024-02-06T11:27:04Z
dc.date.available2024-02-06T11:27:04Z
dc.date.issued2019
dc.identifier.issn2213-2961
dc.identifier.urihttp://hdl.handle.net/10396/27162
dc.description.abstractPurpose The objective of the present study was to determine whether a denervated muscle extract (DmEx) could stimulate satellite cell response in denervated muscle. Methods Wistar rats were divided into 4 groups: normal rats, normal rats treated with DmEx, denervated rats, and denervated rats treated with DmEx. The soleus muscles were examined using immunohistochemical techniques for proliferating cell nuclear antigen, desmin, and myogenic differentiation antigen (MyoD), and electron microscopy was used for analysis of the satellite cells. Results The results indicate that while denervation causes activation of satellite cells, DmEx also induces myogenic differentiation of cells localized in the interstitial space and the formation of new muscle fibers. Although DmEx had a similar effect in nature on innervated and denervated muscles, this response was of greater magnitude in denervated vs. intact muscles. Conclusion Our study shows that treatment of denervated rats with DmEx potentiates the myogenic response in atrophic denervated muscles.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceJournal of Sport and Health Science, 8, 23-31 (2019)es_ES
dc.subjectMuscle atrophyes_ES
dc.subjectMuscle denervationes_ES
dc.subjectMuscle extractes_ES
dc.subjectMyogenic responsees_ES
dc.subjectSatellite celles_ES
dc.subjectSkeletal musclees_ES
dc.titleDenervated muscle extract promotes recovery of muscle atrophy through activation of satellite cells. An experimental studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.jshs.2017.05.007es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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