Sex Steroid Hormones and Tumors in Domestic Animals
Autor
Millán, Yolanda
Guil-Luna, Silvia
Sánchez-Céspedes, Raquel
Martín de las Mulas González-Albo, Juana
Editor
IntechFecha
2013Materia
Domestic animalsTomours
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Sex steroid hormones play a role in the development and control of animal tumours, particularly
in those arising in their target organs. Due to their incidence and prevalence, mammary
tumours of female dogs and cats are among the most frequently studied with focus on
the role of ovarian oestrogen and progesterone. In these tumours, sex steroid hormones
have been shown to act during the three steps of the carcinogenesis cascade: initiation, promotion
and progression. Experimental data have shown the mutagenic effect of oestrogens
[1] while epidemiologic and clinical studies highlighted the role of ovarian hormones as promoters
on mammary tumours in both the dog and the cat [2-9]. Finally, oestrogens and progesterone
further act during tumour progression. Their role in the last two steps of
carcinogenesis makes it possible to control the evolution of the disease