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Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy caucasian population
dc.contributor.author | Moreno-Luna, Rafael | |
dc.contributor.author | Pérez Jiménez, Francisco | |
dc.contributor.author | Marín, Carmen | |
dc.contributor.author | Pérez Martínez, Pablo | |
dc.contributor.author | Gómez, Purificación | |
dc.contributor.author | Jiménez Gómez, Yolanda | |
dc.contributor.author | Delgado-Lista, Javier | |
dc.contributor.author | Moreno, Juan | |
dc.contributor.author | Tanaka, Toshiko | |
dc.contributor.author | Ordovás, José María | |
dc.contributor.author | López Miranda, José | |
dc.date.accessioned | 2024-02-09T13:49:42Z | |
dc.date.available | 2024-02-09T13:49:42Z | |
dc.date.issued | 2007 | |
dc.identifier.uri | http://hdl.handle.net/10396/27381 | |
dc.description.abstract | Background: Apolipoprotein A5 (APOA5) plays an important role in plasma triacylglycerol (TG) homeostasis. Five polymorphisms (1131T>C, c.-3A>G, c.56C>G, IVS3+476G>A, and c.1259T>C) in the APOA5 gene define three common haplotypes (APOA5*1, APOA5*2, and APOA5*3) in Caucasian individuals. Our aim was to determine whether these haplotypes could modulate the postprandial response in young healthy males. Design and Methods: Eighty-eight APO E3/3 volunteers [67 with (−1131T and 56C) APOA5*1 haplotype, 12 with (−1131C and 56C) APOA5*2 haplotype, and nine with (−1131T and 56G) APOA5*3 haplotype] underwent a fat load test consisting of the consumption of 1 g of fat per kilogram body weight and 60,000 IU vitamin A. Blood samples were taken at time 0, at every hour until the sixth hour, and at every 2.5 h until the 11th hour. Total plasma cholesterol (C) and TG, and C, TG, apolipoprotein B-100, apolipoprotein B-48, and retinyl palmitate in lipoprotein fractions were determined. Results: Subjects with the APOA5*2 and APOA5*3 haplotypes had a higher area under the curve of total plasma TG (P = 0.03), large TG-rich lipoprotein (TRL)-TG (P = 0.02), small TRL-TG (P = 0.04), small TRL-C (P = 0.04), large TRL-C (P = 0.03), and small apolipoprotein B100 (P = 0.04) than subjects with the APOA5*1 haplotype. Conclusions: Our findings show that the presence of the APOA5*2 and APOA5*3 haplotypes in the APOA5 gene is associated with a higher postprandial response that could be involved in the higher risk of coronary heart disease associated with the 56G and −1131C alleles. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Endocrine Society | es_ES |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.source | The Journal of Clinical Endocrinology & Metabolism, Volume 92, Issue 6, pp 2280–2285 (2007) | es_ES |
dc.subject | Apolipoprotein A5 | es_ES |
dc.subject | Plasma triacylglycerol (TG) | es_ES |
dc.subject | Caucasian individuals | es_ES |
dc.subject | Blood | es_ES |
dc.subject | Cholesterol | es_ES |
dc.subject | Risk of coronary heart disease | es_ES |
dc.title | Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy caucasian population | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.1210/jc.2006-1802 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |