ListarProducción Científica por tema "DNA demethylation"
Mostrando ítems 1-5 de 5
-
DNA methylation editing by CRISPR-guided excision of 5-methylcytosine
(Elsevier, 2020)Tools for active targeted DNA demethylation are required to increase our knowledge about regulation and specific functions of this important epigenetic modification. DNA demethylation in mammals involve TET-mediated oxidation ... -
Early steps of active DNA demethylation initiated by ROS1 glycosylase require three putative helix-invading residues
(Oxford University Press, 2013)Active DNA demethylation is crucial for epigenetic control, but the underlying enzymatic mechanisms are incompletely understood. REPRESSOR OF SILENCING 1 (ROS1) is a 5-methylcytosine (5-meC) DNA glycosylase/lyase that ... -
Modification of the epigenome in human cancer cells by expression of a DNA demethylase from plants
(Sociedad Española de Mutagénesis Ambiental, 2018) -
Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosineDNA glycosylase to a sequence-specific DNA binding domain
(Taylor & Francis, 2017)DNA methylation is a crucial epigenetic mark associated to gene silencing, and its targeted removal is amajor goal of epigenetic editing. In animal cells, DNA demethylation involves iterative 5mC oxidation byTET enzymes ... -
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity. DNA Repair
(Elsevier, 2022)La desmetilación activa del ADN desempeña un papel importante en el control de los patrones de metilación en los eucariotas. En las plantas, la familia DEMETER-LIKE (DML) de 5-metilcitosina ADN glicosilasas inicia la ...