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dc.contributor.authorPérez-Caballero, Ana I.
dc.contributor.authorGarcía-Ríos, Antonio
dc.contributor.authorGómez-Luna, María J.
dc.contributor.authorGómez-Luna, Purificación
dc.contributor.authorDembinska-Kiec, Aldona
dc.contributor.authorRodríguez-Cantalejo, Fernando
dc.contributor.authorCamargo García, A.
dc.contributor.authorMarín, Carmen
dc.contributor.authorPérez-Martínez, Pablo
dc.contributor.authorDelgado-Lista, Javier
dc.contributor.authorYubero-Serrano, Elena M.
dc.contributor.authorTinahones, Francisco J.
dc.contributor.authorPérez-Jiménez, Francisco
dc.contributor.authorRoche, Helen M.
dc.contributor.authorLópez-Miranda, José
dc.date.accessioned2013-04-25T11:31:43Z
dc.date.available2013-04-25T11:31:43Z
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10396/9801
dc.description.abstractBackground: TCF7L2 rs7903146 is an important genetic factor predicting type 2 diabetes (T2DM) which has also been linked to higher cardiovascular risk. To date, there is little information about the additional impact of this single nucleotide polymorphism (SNP) beyond glucose metabolism. Methodology/Principal Findings: We studied whether rs7903146 influenced postprandial lipid metabolism in three different populations (healthy young men, metabolic syndrome (MetS) patients and elderly persons). Eighty-eight healthy males were submitted to a single saturated fatty acid-rich test meal. Additionally, 110 middle-aged MetS patients and 20 healthy elderly persons ($65 years) were submitted to three different dietary models followed by test meals. Minor allele homozygotes for rs7903146 showed a worse postprandial lipemia profile in young males, as seen by a lower HDLcholesterol and Apo A1 concentration during the postprandial lipemia and a trend towards higher triglycerides (TG), than the other genotypes. In healthy elderly persons, carriers of the minor allele showed higher total cholesterol, LDL-cholesterol, Apo B and TG in the fasting state, and a higher postprandial area under the curve for total cholesterol, Apo B, smalltriglyceride rich lipoprotein (TRL) cholesterol and small-(TRL) triglycerides. These results were accompanied by differential changes in adipokines. We did not observe any influence of rs7903146 on the postprandium of MetS patients. Conclusions/Significance: Healthy young males and elderly persons who are carriers of the mutant allele for rs7903146 have an impaired postprandial lipid metabolism that may be mediated by an alteration in adipokine regulation, and may be related to the higher cardiovascular risk observed in these persons.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherPublic Library Of Science (PLOS)es_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourcePLoS ONE 7(8), 1-8 (2012)es_ES
dc.subjectLipid metabolismes_ES
dc.subjectGene expressiones_ES
dc.subjectrs7903146 variationes_ES
dc.titleEffects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populationses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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