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dc.contributor.authorFernández del Río, Lucía
dc.contributor.authorGutiérrez-Casado, Elena
dc.contributor.authorVarela-López, Alfonso
dc.contributor.authorVillalba, José Manuel
dc.date.accessioned2017-11-07T08:44:46Z
dc.date.available2017-11-07T08:44:46Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10396/15324
dc.description.abstractAging is a multifactorial and tissue-specific process involving diverse alterations regarded as the “hallmarks of aging”, which include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intracellular communication. Virtually all these hallmarks are targeted by dietary olive oil, particularly by virgin olive oil, since many of its beneficial effects can be accounted not only for the monounsaturated nature of its predominant fatty acid (oleic acid), but also for the bioactivity of its minor compounds, which can act on cells though both direct and indirect mechanisms due to their ability to modulate gene expression. Among the minor constituents of virgin olive oil, secoiridoids stand out for their capacity to modulate many pathways that are relevant for the aging process. Attenuation of aging-related alterations by olive oil or its minor compounds has been observed in cellular, animal and human models. How olive oil targets the hallmarks of aging could explain the improvement of health, reduced risk of aging-associated diseases, and increased longevity which have been associated with consumption of a typical Mediterranean diet containing this edible oil as the predominant fat sourcees_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceMolecules 21, 163 (2016)es_ES
dc.subjectDNA damagees_ES
dc.subjectFatty acidses_ES
dc.subjectHallmarks of aginges_ES
dc.subjectMediterranean dietes_ES
dc.subjectOlive oiles_ES
dc.subjectOxidative stresses_ES
dc.subjectPolyphenolses_ES
dc.subjectSenescencees_ES
dc.titleOlive Oil and the Hallmarks of Aginges_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/molecules21020163es_ES
dc.relation.projectIDGobierno de España. BFU2011-23578es_ES
dc.relation.projectIDJunta de Andalucía. P09-CVI-4887es_ES
dc.relation.projectIDJunta de Andalucía. BIO-276es_ES
dc.relation.projectIDGobierno de España. CTS-627es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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