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dc.contributor.authorOlaya-Abril, Alfonso
dc.contributor.authorPrados Rosales, Rafael
dc.contributor.authorGonzález Reyes, José Antonio
dc.contributor.authorCasadevall, Arturo
dc.contributor.authorPirofski, Liise-anne
dc.contributor.authorRodríguez-Ortega, Manuel J.
dc.date.accessioned2021-11-23T12:58:54Z
dc.date.available2021-11-23T12:58:54Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10396/22185
dc.description.abstractBacterial extracellular vesicles are membranous ultrastructures released from the cell surface. They play important roles in the interaction between the host and the bacteria. In this work, we show how extracellular vesicles produced by four different serotypes of the important human pathogen, Streptococcus pneumoniae, are internalized by murine J774A.1 macrophages via fusion with the membrane of the host cells. We also evaluated the capacity of pneumococcal extracellular vesicles to elicit an immune response by macrophages. Macrophages treated with the vesicles underwent a serotype-dependent transient loss of viability, which was further reverted. The vesicles induced the production of proinflammatory cytokines, which was higher for serotype 1 and serotype 8-derived vesicles. These results demonstrate the biological activity of extracellular vesicles of clinically important pneumococcal serotypes.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourcePathogens 10(12), 1530 (2021)es_ES
dc.subjectHost-pathogen interactiones_ES
dc.subjectStreptococcus pneumoniaees_ES
dc.subjectMembrane vesicleses_ES
dc.subjectImmune responsees_ES
dc.titleExtracellular Vesicles from Different Pneumococcal Serotypes Are Internalized by Macrophages and Induce Host Immune Responseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/pathogens10121530es_ES
dc.relation.projectIDJunta de Andalucía. AGR164es_ES
dc.relation.projectIDJunta de Andalucía. AGR256es_ES
dc.relation.projectIDGobierno de España. PID2019-110240RBes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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