Listar DBCFI-Artículos, capítulos... por autor "3388e350-4946-446f-bcf0-86547b968c85"

Mostrando ítems 1-20 de 30

    • A Novel Human Ghrelin Variant (In1-Ghrelin) and Ghrelin-O-Acyltransferase Are Overexpressed in Breast Cancer: Potential Pathophysiological Relevance 

      Gahete Ortiz, Manuel D.; Córdoba-Chacón, José; Hergueta-Redondo, Marta; Martínez-Fuentes, Antonio J.; Kineman, Rhonda D.; Moreno-Bueno, Gema; Luque, Raúl M.; Castaño, Justo P. (Public Library Of Science (PLOS), 2011)
      The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a 117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a ...

    • Antagonists of Growth Hormone-Releasing Hormone Inhibit the Growth of Pituitary Adenoma Cells by Hampering Oncogenic Pathways and Promoting Apoptotic Signaling 

      Gesmundo, Iacopo; Granato, Giuseppina; Fuentes-Fayos, Antonio C.; Álvarez, Clara V.; Diéguez, Carlos; Zatelli, Maria Chiara; Congiusta, Noemi; Banfi, Dana; Prencipe, Nunzia; Leone, Sheila; Brunetti, Luigi; Castaño, Justo P.; Luque, Raúl M.; Cai, Renzhi; Sha, Wei; Ghigo, Ezio; Schally, Andrew V.; Granata, Riccarda (MDPI, 2021)
      Pituitary adenomas (PAs) are intracranial tumors, often associated with excessive hormonal secretion and severe comorbidities. Some patients are resistant to medical therapies; therefore, novel treatment options are needed. ...

    • Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study 

      Gahete Ortiz, Manuel D.; Río Moreno, Mercedes del; Carpio Camargo, Antonio José; Alcalá Díaz, Juan Francisco; Alors-Pérez, Emilia; Delgado-Lista, Javier; Reyes Pupo, Oscar Gabriel; Ventura, Sebastián; Pérez Martínez, Pablo; Castaño, Justo P.; López Miranda, José; Luque, Raúl M. (Elsevier, 2018)
      Background: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, ...

    • Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer 

      Jiménez-Vacas, J.M.; Gómez Gómez, Enrique; Montero-Hidalgo, Antonio J.; Herrero-Aguayo, V.; L-López, Fernando; Sánchez-Sánchez, Rafael; Guler, Ipek; Blanca, Ana; Méndez-Vidal, María José; Carrasco, Julia; López-Miranda, José; Requena-Tapia, M.J.; Castaño, Justo P.; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2019)
      Recent data suggested that plasma Ghrelin O-Acyl Transferase enzyme (GOAT) levels could represent a new diagnostic biomarker for prostate cancer (PCa). In this study, we aimed to explore the diagnostic and prognostic/agg ...

    • Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells 

      León González, A.J.; Sáez Martínez, Prudencio; Jiménez-Vacas, J.M.; Herrero-Aguayo, V.; Montero-Hidalgo, Antonio J.; Gómez Gómez, Enrique; Madrona, Andrés; Castaño, Justo P.; Espartero, José L.; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2021)
      A high adherence to a Mediterranean diet has been related to numerous beneficial effects in human health, including a lower incidence and mortality of prostate cancer (PCa). Olive oil is an important source of phenolic ...

    • Desarrollo de un modelo docente adaptado a los criterios metodológicos 

      Ruiz, Antonio; Gaytán, Francisco; Lucena, Concepción; Villalba, José Manuel; Vázquez Martínez, Rafael; Martínez-Fuentes, Antonio J.; Gracia-Navarro, F.; González Reyes, José Antonio; García-Navarro, Socorro; Castaño, Justo P.; Alcaín Tejada, F.J.; Burón, Isabel; Malagón, María M. (Consejo Social de la Universidad de Córdoba, 2008)

    • Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study 

      Río Moreno, Mercedes del; Luque, Raúl M.; Rangel Zúñiga, Oriol Alberto; Alors-Pérez, Emilia; Alcalá Díaz, Juan Francisco; Roncero-Ramos, Irene; Camargo García, A.; Gahete Ortiz, Manuel D.; López-Miranda, José; Castaño, Justo P. (MDPI, 2020)
      Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely ...

    • La ecoinnovación en el sector agroalimentario: ¿qué puede aportar el Campus? 

      Castaño, Justo P.; Domínguez García-Barquero, Ricardo (Campus de Excelencia Internacional Agroalimentario, 2012)

    • Endocrinología celular y molecular 

      García Navarro, S.; Ruiz Navarro, A.; Martínez Fuentes, A.J.; Vázquez Martínez, Rafael; Durán Prado, M.; Rodríguez Pacheco, F.; Molina Sánchez, M.; Cruz García, D.; Gutiérrez Pascual, E.; Díaz-Ruiz Ruiz, A.; Gahete Ortiz, Manuel D.; Pulido Toledano, M.; Castaño, Justo P.; Malagón, María M. (Universidad de Córdoba, 2009)
      El correcto funcionamiento y homeostasis del organismo requieren un control de la secreción hormonal, cuyos defectos producen graves desórdenes endocrinos y metabólicos. Esta regulación mediada por la interacción ...

    • Enzima GOAT como biomarcador de diagnóstico del cáncer de próstata 

      Castaño, Justo P.; Luque, Raúl M.; Gahete Ortiz, Manuel D.; Hormaechea Agulla, Daniel; Requena-Tapia, M.J.; Gómez Gómez, Enrique; Carrasco, Julia; Ibáñez, Alejandro; Moreno, María del Mar; Valero, José (Oficina de Transferencia de Resultados de la Investigación, 2020)

    • Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors 

      Herrera-Martínez, Aura D.; Gahete Ortiz, Manuel D.; Sánchez-Sánchez, Rafael; Alors-Pérez, Emilia; Pedraza-Arévalo, Sergio; Serrano-Blanch, Raquel; Martínez-Fuentes, Antonio J.; Castaño, Justo P.; Luque, Raúl M.; Gálvez-Moreno, M. Ángeles (Nature.com, 2018)
      Objectives: The association between the presence and alterations of the components of the ghrelin system and the development and progression of neuroendocrine tumors (NETs) is still controversial and remains unclear. Methods: ...

    • Identification of novel genes involved in the plasticity of pituitary melanotropes in amphibians 

      Malagón, María M.; Cruz García, D.; Díaz-Ruiz Ruiz, A.; Peinado, Juan R.; Pulido, Marina R.; Araújo, J.; García Navarro, S.; Gracia-Navarro, F.; Castaño, Justo P.; Vázquez Martínez, Rafael (New York Academy os Sciences, 2009)
      Melanotrope cells from the amphibian intermediate lobe are composed of two subpopulations that exhibit opposite secretory behavior: hypersecretory and hormone-storage hyposecretory melanotropes. Isolation of these ...

    • In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features 

      Ibáñez-Costa, Alejandro; Gahete Ortiz, Manuel D.; Rivero-Cortés, Esther; Rincón-Fernández, David; Nelson, Richard; Beltrán, Manuel; Riva, Andrés de la; Japón, Miguel A.; Venegas-Moreno, Eva; García-Arnés, Juan A.; Soto-Moreno, Alfonso; Morgan, Jennifer; Tsomaia, Natia; Culler, Michael D.; Diéguez, Carlos; Castaño, Justo P.; Luque, Raúl M.; Gálvez-Moreno, M. Ángeles (Nature.com, 2015)
      Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets. The ghrelin ...

    • Journal article resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways 

      Rodríguez Pacheco, F.; Vázquez Martínez, Rafael; Martínez-Fuentes, Antonio J.; Pulido, Marina R.; Gahete Ortiz, Manuel D.; Vaudry, Hubert; Gracia-Navarro, F.; Diéguez, Carlos; Castaño, Justo P.; Malagón, María M. (Endocrine Society, 2009)
      The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function. Although adipose tissue is the primary source of resistin, it is also ...

    • Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study 

      Buell-Acosta, Julieth Daniela; Garces, Maria Fernanda; Parada-Baños, Arturo José; Angel-Muller, Edith; Paéz, María Carolina; Eslava-Schmalbach, Javier; Escobar-Córdoba, Franklin; Caminos-Cepeda, Sofía Alexandra; Lacunza, Ezequiel; Castaño, Justo P.; Nogueiras, Rubén; Diéguez, Carlos; Ruiz-Parra, Ariel Iván; Caminos, Jorge Eduardo (MDPI, 2022)
      Fibroblast growth factor 21 (FGF-21) is an endocrine factor involved in glucose and lipid metabolism that exerts pleiotropic effects. The aim of this study was to investigate the serum FGF-21 profile in healthy and mild ...

    • Melanotrope Secretory Cycle is Regulated by Physiological Inputs via the Hypothalamus 

      Vázquez Martínez, Rafael; Castaño, Justo P.; Tonon, Marie Christine; Vaudry, Hubert; Gracia-Navarro, F.; Malagón, María M. (2017-03-17)
      Previously, it has been shown that background color conditions regulate the overall activity of the frog intermediate lobe by varying the proportions of the two subtypes of melanotropes existing in the gland, the highly ...

    • Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice 

      Biagetti, Betina; Herance, J.R.; Ferrer, Roser; Aulinas, Anna; Palomino-Schätzlein, Martina; Mesa, Jordi; Castaño, Justo P.; Luque, Raúl M.; Simó, Rafael (MDPI, 2019)
      Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the disease and the associated ...

    • Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly 

      Martín, Juan Francisco; Muñoz-Bravo, José L.; Ibáñez-Costa, Alejandro; Fernández-Maza, Laura; Balcerzyk, Marcin; Leal Campanario, Rocío; Luque, Raúl M.; Castaño, Justo P.; Venegas-Moreno, Eva; Soto-Moreno, Alfonso; Leal-Cerro, Alfonso; Cano, David A. (Nature Research, 2015)
      Acromegaly is a disorder resulting from excessive production of growth hormone (GH) and consequent increase of insulin-like growth factor 1 (IGF-I), most frequently caused by pituitary adenomas. Elevated GH and IGF-I levels ...

    • Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue 

      Pulido, Marina R.; Rabanal Ruiz, Yoana; Almabouada, Farid; Díaz-Ruiz, Alberto; Burrel, María A; Vázquez, María J.; Castaño, Justo P.; Kineman, Rhonda D.; Luque, Raúl M.; Diéguez, Carlos; Vázquez-Martínez, Rafael; Malagón, María M. (Society for Endocrinology, 2013)
      There is increasing evidence that proteins associated with lipid droplets (LDs) play a key role in the coordination of lipid storage and mobilization in adipocytes. The small GTPase, RAB18, has been recently identified as ...

    • Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer 

      Gómez-Gómez, E.; Jiménez-Vacas, J.M.; Pedraza-Arévalo, Sergio; López-López, F.; Herrero-Aguayo, V.; Hormaechea Agulla, Daniel; Valero-Rosa, J.; Ibáñez-Costa, Alejandro; León González, A.J.; Sánchez-Sánchez, Rafael; Gónzalez Serrano, T.; Requena-Tapia, M.J.; Castaño, Justo P.; Carrasco-Valiente, J.; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2019)
      Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the ...