• A Novel Human Ghrelin Variant (In1-Ghrelin) and Ghrelin-O-Acyltransferase Are Overexpressed in Breast Cancer: Potential Pathophysiological Relevance 

      Gahete Ortiz, Manuel D.; Córdoba-Chacón, José; Hergueta-Redondo, Marta; Martínez-Fuentes, Antonio J.; Kineman, Rhonda D.; Moreno-Bueno, Gema; Luque, Raúl M.; Castaño, Justo P. (Public Library Of Science (PLOS), 2011)
      The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a 117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a ...
    • Desarrollo de un modelo docente adaptado a los criterios metodológicos 

      Ruiz, Antonio; Gaytán, Francisco; Lucena, Concepción; Villalba, José Manuel; Vázquez Martínez, Rafael; Martínez-Fuentes, Antonio J.; Gracia-Navarro, F.; González Reyes, José Antonio; García-Navarro, Socorro; Castaño, Justo P.; Alcaín Tejada, F.J.; Burón, Isabel; Malagón, María M. (Consejo Social de la Universidad de Córdoba, 2008)
    • Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors 

      Herrera-Martínez, Aura D.; Gahete Ortiz, Manuel D.; Sánchez-Sánchez, Rafael; Alors-Pérez, Emilia; Pedraza-Arévalo, Sergio; Serrano-Blanch, Raquel; Martínez-Fuentes, Antonio J.; Castaño, Justo P.; Luque, Raúl M.; Gálvez-Moreno, M. Ángeles (Nature.com, 2018)
      Objectives: The association between the presence and alterations of the components of the ghrelin system and the development and progression of neuroendocrine tumors (NETs) is still controversial and remains unclear. Methods: ...
    • Journal article resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways 

      Rodríguez Pacheco, F.; Vázquez Martínez, Rafael; Martínez-Fuentes, Antonio J.; Pulido, Marina R.; Gahete Ortiz, Manuel D.; Vaudry, Hubert; Gracia-Navarro, F.; Diéguez, Carlos; Castaño, Justo P.; Malagón, María M. (Endocrine Society, 2009)
      The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function. Although adipose tissue is the primary source of resistin, it is also ...
    • Rab18 is reduced in pituitary tumors cusing acromegaly and its overexpression reverts growth hormone hypersecretion 

      Vázquez Martínez, Rafael; Martínez-Fuentes, Antonio J.; Pulido, Marina R.; Jiménez Reina, L.; Quintero, Ana; Leal-Cerro, Alfonso; Soto, Alfonso; Webb, Susan M.; Sucunza, Nuria; Bartumeus, Frederic; Benito-López, Pedro; Galvez-Moreno, María A.; Castaño, Justo P.; Malagón, María M. (Oxford Academic, 2008)
      Context: Rab proteins regulate the sequential steps of intracellular membrane transport. Alterations of these GTPases and their associated proteins are emerging as the underlying cause for several human diseases involving ...
    • Role of Endogenous Cortistatin in the Regulation of Ghrelin System Expression at Pancreatic Level under Normal and Obese Conditions 

      Chanclón García, Belén; Luque, Raúl M.; Córdoba-Chacón, José; Gahete Ortiz, Manuel D.; Pozo-Salas, Ana I.; Castaño, Justo P.; Gracia-Navarro, F.; Martínez-Fuentes, Antonio J. (Public Library Of Science (PLOS), 2013)
      Ghrelin-system components [native ghrelin, In1-ghrelin, Ghrelin-O-acyltransferase enzyme (GOAT) and receptors (GHS-Rs)] are expressed in a wide variety of tissues, including the pancreas, where they exert different ...
    • Uso de mandos interactivos de respuesta como base para la mejora de la docencia en los Grados impartidos en la Facultad de Ciencias 

      Pérez-Vicente, C.; Siles López, José Ángel; Ruiz Roldán, Carmen; Martínez-Fuentes, Antonio J.; García-Ortiz, M.V.; Martín-Romero, M.T.; Bárcena Ruiz, José Antonio; Padilla Peña, Carmen Alicia; Márquez Espinosa, Ramiro; Vázquez Martínez, Rafael; Díaz Soriano, Antonio Manuel; Marinas, Alberto; Delgado Marzo, Juan Manuel; López Toledano, Azahara; Pérez-Morales, M.; Miguel, Gustavo de (UCOPress, 2017)
      La implantación de los nuevos Grados dentro del EEES supone un nuevo enfoque metodológico, pero sobre todo evaluador. El profesor debe esforzarse en ser capaz de valorar no sólo el nivel de conocimientos del alumnado sobre ...