Listar DBCFI-Artículos, capítulos... por fecha de publicación
Mostrando ítems 41-60 de 188
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Endocrinología celular y molecular
(Universidad de Córdoba, 2009)El correcto funcionamiento y homeostasis del organismo requieren un control de la secreción hormonal, cuyos defectos producen graves desórdenes endocrinos y metabólicos. Esta regulación mediada por la interacción ... -
Identification of novel genes involved in the plasticity of pituitary melanotropes in amphibians
(New York Academy os Sciences, 2009)Melanotrope cells from the amphibian intermediate lobe are composed of two subpopulations that exhibit opposite secretory behavior: hypersecretory and hormone-storage hyposecretory melanotropes. Isolation of these ... -
Journal article resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways
(Endocrine Society, 2009)The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function. Although adipose tissue is the primary source of resistin, it is also ... -
Utilidad de los agonistas, moduladores selectivos y antagonistas puros del receptor de estrógenos en estudios morfofuncionales del útero de la rata
(RACVAO, 2010)De acuerdo con el Instituto Nacional de la Salud, la especie murina es una de las especies más importantes en el estudio de la fisiología y de un gran número de procesos que tienen lugar en el organismo, tanto en la especie ... -
Complex I-Associated Hydrogen Peroxide Production Is Decreased and Electron Transport Chain Enzyme Activities Are Altered in n-3 Enriched fat-1 Mice
(Public Libray of Science (PLOS), 2010)The polyunsaturated nature of n-3 fatty acids makes them prone to oxidative damage. However, it is not clear if n-3 fatty acids are simply a passive site for oxidative attack or if they also modulate mitochondrial reactive ... -
The stromal-vascular fraction of adipose tissue contributes to major differences between subcutaneous and visceral fat depots
(Wiley, 2010)Adipose tissue represents a complex tissue both in terms of its cellular composition, as it includes mature adipocytes and the various cell types comprising the stromal-vascular fraction (SVF), and in relation to the ... -
Implicación activa del alumnado en el sistema de evaluación continua en el aula
(Consejo Social de la Universidad de Córdoba, 2010) -
Rab18 Dynamics in Adipocytes in Relation to Lipogenesis, Lipolysis and Obesity
(Public Libray of Science (PLOS), 2011)Lipid droplets (LDs) are organelles that coordinate lipid storage and mobilization, both processes being especially important in cells specialized in managing fat, the adipocytes. Proteomic analyses of LDs have consistently ... -
Metabolic Impact of Adult-Onset, Isolated, Growth Hormone Deficiency (AOiGHD) Due to Destruction of Pituitary Somatotropes
(Public Library Of Science (PLOS), 2011)Growth hormone (GH) inhibits fat accumulation and promotes protein accretion, therefore the fall in GH observed with weight gain and normal aging may contribute to metabolic dysfunction. To directly test this hypothesis ... -
Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition
(Blackwell Publishing, 2011)Much attention has been drawn to the possible involvement of hypothalamic inflammation in the pathogenesis of metabolic disorders, especially in response to a high-fat diet. Microglia, the macrophages of the central nervous ... -
Intensification of Antiretroviral Therapy with a CCR5 Antagonist in Patients with Chronic HIV-1 Infection: Effect on T Cells Latently Infected
(Public Library Of Science (PLOS), 2011)Objective: The primary objective was to assess the effect of MVC intensification on latently infected CD4+ T cells in chronically HIV-1-infected patients receiving antiretroviral therapy. Methods: We performed an open-label ... -
A Novel Human Ghrelin Variant (In1-Ghrelin) and Ghrelin-O-Acyltransferase Are Overexpressed in Breast Cancer: Potential Pathophysiological Relevance
(Public Library Of Science (PLOS), 2011)The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a 117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a ... -
Factores limitantes del rendimiento físico del toro bravo durante la lidia
(RACVAO, 2011)Con este trabajo se persigue aportar nuevas ideas sobre la fi siopatología del ejercicio en el toro bravo, siendo el objetivo principal, valorar los cambios metabólicos que se presentan deforma secundaria a las lesiones ... -
Proteomic profiling of adipose tissue from Zmpste24(-/-) Mice, a model of Lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing
(Science Direct, 2011)Lipodystrophy is a major disease involving severe alterations of adipose tissue distribution and metabolism. Mutations in genes encoding the nuclear envelope protein lamin A or its processing enzyme, the metalloproteinase ... -
Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity
(PLOS, 2011)Lipid droplets (LDs) are organelles that coordinate lipid storage and mobilization, both processes being especially important in cells specialized in managing fat, the adipocytes. Proteomic analyses of LDs have consistently ... -
Comparative insights of the kisspeptin/kisspeptin receptor system: lessons from non-mammalian vertebrates
(Elsevier, 2012)Kisspeptins, the peptide products of the Kiss1 gene, were initially identified in mammals as ligands of the G protein‐coupled receptor 54 (GPR54; also termed Kiss1R) with ability to suppress tumor metastasis. In late 2003, ... -
Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin
(Public Library Of Science (PLOS), 2012)Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase ... -
3-Phenylcoumarins as Inhibitors of HIV-1 Replication
(MDPI, 2012)We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition ... -
Role of SST, CORT and ghrelin, and its receptors at the endocrine pancreas
(Frontiers In..., 2012) -
Diseño de una nueva asignatura dirigida al aprendizaje, integración y evaluación de competencias transversales en el grado de Medicina para la aplicación y mejora de su perfil laboral
(Consejo Social de la Universidad de Córdoba, 2012)La propuesta presenta la creación de una nueva asignatura en el grado de Medicina: Aplicación Clínica de las Ciencias Médicas Básicas –cuyo desarrollo ha implicado una inversión de 6.000 euros– que se imparte en el ...