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Quality of Life: Changes in Self-Perception in People with Down Syndrome as a Result of Being Part of a Football/Soccer Team. Self-Reports and External Reports
(MDPI, 2021)
The hypothesis posed was whether being part of a football/soccer team influenced the quality of life (QL) of the people who participated in it since their perception of themselves is enhanced by factors, such as ...
Influencia de la alimentación con forrajes con alta carga de micotoxinas en parámetros fisiológicos de bienestar animal y lesiones orgánicas en ovinos
(RACVAO, 2017)
La obtención de forrajes en verano como el maíz tiene el gran problema de que puede conllevar una alta carga de micotoxinas, producidas en el crecimiento del forraje por hongos, y que al emplearse en vacuno lechero, pueden ...
Welfare Quality® for dairy cows: towards a sensor-based assessment
(Cambridge University Press, 2020)
This Research Reflection addresses the possibilities for Welfare Quality® to evolve from an assessment method based on data gathered on punctual visits to the farm to an assessment method based on sensor data. This approach ...
Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer
(Wiley, 2023)
S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme that has been suggested to play a tumor suppressor role, although the mechanisms responsible are still largely unclear. In this study, we show that GSNOR ...
Journal article resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways
(Endocrine Society, 2009)
The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function. Although adipose tissue is the primary source of resistin, it is also ...
Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma
(Elsevier, 2020)
Splicing alterations represent an actionable cancer hallmark. Splicing factor 3B subunit 1 (SF3B1) is a crucial splicing factor that can be targeted pharmacologically (e.g. pladienolide-B). Here, we show that SF3B1 is ...
Peptides derived from the extracellular domain of the somatostatin receptor splicing variant 1 SST5TMD4 increase malignancy in multiple cancer cell types
(Elsevier, 2019)
Extracellular fragments derived from plasma membrane receptors can play relevant roles in the development/progression of tumor pathologies, thereby offering novel diagnostic or therapeutic opportunities. The truncated ...
Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing
(Wiley, 2022)
Introduction: Altered splicing landscape is an emerging cancer hallmark; however, the dysregulation and implication of the cellularmachinery controlling this process (spliceosome components and splicing factors) in ...
Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study
(Elsevier, 2018)
Background: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, ...