Search

Now showing items 1-5 of 5

Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition

Tapia-González, S.; García-Segura, L.M.; Tena-Sempere, Manuel; Frago, L.M.; Castellano, J.M.; Fuente-Martín, E.; García-Cáceres, C.; Argente, J.; Chowen, J.A. (Blackwell Publishing, 2011)

Much attention has been drawn to the possible involvement of hypothalamic inflammation in the pathogenesis of metabolic disorders, especially in response to a high-fat diet. Microglia, the macrophages of the central nervous ...

Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation

Frühbeck, Gema; Balaguer, Inmaculada; Méndez-Giménez, Leire; Valentí, Víctor; Becerril, Sara; Catalán, Victoria; Gómez-Ambrosi, Javier; Silva, Camilo; Salvador, Javier; Calamita, Giuseppe; Malagón, María M.; Rodríguez, Amaia (MDPI, 2020)

Aquaporin-11 (AQP11) is expressed in human adipocytes, but its functional role remains unknown. Since AQP11 is an endoplasmic reticulum (ER)-resident protein that transports water, glycerol, and hydrogen peroxide (H2O2), ...

Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue

Novelle, Marta G.; Vázquez, María J.; Peinado, Juan R.; Martinello, Kátia D.; López, Miguel; Luckman, Simon M.; Tena-Sempere, Manuel; Malagón, María M.; Nogueiras, Rubén; Diéguez, Carlos (Nature Research, 2017)

During their lifetime, females are subjected to different nutritional and hormonal factors that could increase the risk of obesity and associated comorbidities. From early postnatal periods until the postmenopausal phase, ...

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Opazo-Ríos, Lucas; Mas, Sebastián; Marín-Royo, Gema; Mezzano, Sergio; Gómez-Guerrero, Carmen; Moreno, Juan Antonio; Egido, J. (MDPI, 2020)

Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose ...

The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health

Clemente-Postigo, Mercedes; Tinahones, Alberto; Bekay, Rajaa El; Malagón, María M.; Tinahones, Francisco J. (MDPI, 2020)

White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT ...