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Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer

Jiménez-Vacas, J.M.; Gómez Gómez, Enrique; Montero-Hidalgo, Antonio J.; Herrero-Aguayo, V.; L-López, Fernando; Sánchez-Sánchez, Rafael; Guler, Ipek; Blanca, Ana; Méndez-Vidal, María José; Carrasco, Julia; López-Miranda, José; Requena-Tapia, M.J.; Castaño, Justo P.; Gahete Ortiz, Manuel D.; Luque, Raul M. (MDPI, 2019)

Recent data suggested that plasma Ghrelin O-Acyl Transferase enzyme (GOAT) levels could represent a new diagnostic biomarker for prostate cancer (PCa). In this study, we aimed to explore the diagnostic and prognostic/agg ...

Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness Features

Vázquez Borrego, María del Carmen; Fuentes-Fayos, Antonio C.; Venegas-Moreno, Eva; Rivero-Cortés, Esther; Dios, Elena; Moreno Moreno, Paloma; Madrazo-Atutxa, Ainara; Remón, Pablo; Solivera, Juan; Wildemberg, Luiz E.; Kasuki, Leandro; López-Fernández, Judith M.; Gadelha, Mônica R.; Gálvez-Moreno, M. Ángeles; Soto-Moreno, Alfonso; Gahete Ortiz, Manuel D.; Castaño, Justo P.; Luque, Raúl M. (MDPI, 2019)

Pituitary neuroendocrine tumors (PitNETs) constitute approximately 15% of all brain tumors, and most have a sporadic origin. Recent studies suggest that altered alternative splicing and, consequently, appearance of aberrant ...

Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice

Biagetti, Betina; Herance, J.R.; Ferrer, Roser; Aulinas, Anna; Palomino-Schätzlein, Martina; Mesa, Jordi; Castaño, Justo P.; Luque, Raúl M.; Simó, Rafael (MDPI, 2019)

Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the disease and the associated ...

Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer

Gómez-Gómez, E.; Jiménez-Vacas, J.M.; Pedraza-Arévalo, Sergio; López-López, F.; Herrero-Aguayo, V.; Hormaechea Agulla, Daniel; Valero-Rosa, J.; Ibáñez-Costa, Alejandro; León González, A.J.; Sánchez-Sánchez, Rafael; Gónzalez Serrano, T.; Requena-Tapia, M.J.; Castaño, Justo P.; Carrasco-Valiente, J.; Gahete Ortiz, Manuel D.; Luque, R.M. (MDPI, 2019)

Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the ...